Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream Cγ genes
| Autor: | John E. Butler, Kelly M. Lager, Nancy Wertz, XiuZhu Sun, Amy L. Vincent, Eraldo L. Zanella |
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| Rok vydání: | 2013 |
| Předmět: |
Swine
Immunology Adaptive Immunity Antibodies Viral Cell Line Peyer's Patches Dogs Fetus Influenza A Virus H1N1 Subtype Immune system Orthomyxoviridae Infections Antibody Repertoire Antigen Immunity Animals Immunology and Allergy Swine Diseases biology Original Articles Acquired immune system Immunoglobulin Class Switching Virology Animals Newborn Immunoglobulin M Immunoglobulin class switching Polyclonal antibodies Immunoglobulin G biology.protein Somatic Hypermutation Immunoglobulin Antibody |
| Zdroj: | Immunology. 138:134-144 |
| ISSN: | 0019-2805 |
| DOI: | 10.1111/imm.12018 |
| Popis: | Infection of germ-free isolator piglets with swine influenza (S-FLU) that generates dsRNA during replication causes elevation of immunoglobulins in serum and bronchoalveolar lavage, a very weak response to trinitrophenyl conjugates but an immune response to S-FLU. The increased immunoglobulin levels result mainly from the polyclonal activation of B cells during the infection, but model antigen exposure may contribute. The 10-fold increase in local and serum IgG accompanies a 10-fold decrease in the transcription of IgG3 in the tracheal-bronchial lymph nodes and in the ileal Peyer's patches. Infection results in class switch recombination to downstream Cγ genes, which diversify their repertoire; both features are diagnostic of adaptive immunity. Meanwhile the repertoires of IgM and IgG3 remain undiversified suggesting that they encode innate, natural antibodies. Whereas IgG3 may play an initial protective role, antibodies encoded by downstream Cγ genes with diversified repertoires are predicted to be most important in long-term protection against S-FLU. |
| Databáze: | OpenAIRE |
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