Serum fetuin-A levels are independently correlated with vascular endothelial growth factor and C-reactive protein concentrations in type 2 diabetic patients with diabetic retinopathy
| Autor: | Huixiang Ju, Hongmei Chen, Dongmei Jiang, Mingzhong Sun, Fei Ji, Qing-ping Fu, Hong-Bin Ji, Zhongwei Zhou |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A 0301 basic medicine medicine.medical_specialty endocrine system diseases alpha-2-HS-Glycoprotein Clinical Biochemistry 030209 endocrinology & metabolism Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Diabetic Nephropathies Aged biology business.industry Biochemistry (medical) C-reactive protein nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Diabetic retinopathy Middle Aged medicine.disease Fetuin Vascular endothelial growth factor Vascular endothelial growth factor A C-Reactive Protein 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 chemistry biology.protein Female business alpha-2-HS-glycoprotein Retinopathy |
| Zdroj: | Clinica Chimica Acta. 455:113-117 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2016.02.003 |
| Popis: | The higher expression of vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) is associated with the development of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM). Fetuin-A is shown to have proangiogenic and proinflammatory effects.This study included 245 T2DM patients consisting of 95 cases with non-diabetic retinopathy (NDR), 78 cases with non-proliferative diabetic retinopathy (NPDR) and 72 cases with proliferative diabetic retinopathy (PDR), in addition to 65 healthy controls. Serum fetuin-A, VEGF and CRP concentrations and related parameters were measured.Significant positive correlations were found between fetuin-A and VEGF and CRP, and between VEGF and CRP in T2DM patients (all p0.001). After adjustment for confounders, fetuin-A was correlated independently with VEGF and CRP in NPDR and PDR patients, but not in NDR subjects. In addition, fetuin-A was correlated independently with HOMA-IR (all 4 groups), HbA1c (NDR, NPDR and PDR groups) and duration of diabetes (PDR group). When compared with NDR and control subjects, NPDR and PDR patients had higher HOMA-IR.Serum fetuin-A concentrations are independently correlated with VEGF and CRP concentrations in T2DM patients with DR, but not in NDR subjects. |
| Databáze: | OpenAIRE |
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