A trial of doramectin injection and ivermectin spot-on for treatment of rabbits artificially infested with the ear mite 'Psoroptes cuniculi'
| Autor: | Moshira El-Abasy, Sh.S. Sorour, Eman K. Bazh, Nagwa M. Elhawary, Khaled Sultan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Insecticides Mite Infestations Veterinary medicine 040301 veterinary sciences Administration Topical Injections Subcutaneous Mange Positive control 0403 veterinary science Random Allocation 03 medical and health sciences Ivermectin parasitic diseases medicine Animals Doramectin Psoroptes cuniculi Nymph General Veterinary biology Acaricide business.industry Psoroptidae 04 agricultural and veterinary sciences General Medicine medicine.disease biology.organism_classification 030104 developmental biology Rabbits business Ear mite medicine.drug |
| Zdroj: | Polish Journal of Veterinary Sciences. 20:521-525 |
| ISSN: | 2300-2557 |
| DOI: | 10.1515/pjvs-2017-0063 |
| Popis: | The ear mite “Psoroptes cuniculi” is the main cause of ear mange, a highly contagious parasitic skin disease in rabbits all over the world. In the current work, a preliminary therapeutic trial to study the effect of the broad use acaricides doramectin and ivermectin on P. cuniculi was performed on artificially infested rabbits. Twenty five adult New Zealand white rabbits were used in this study. The rabbits were assigned randomly into five groups/ 5 rabbits in each group. Each rabbit was experimentally infested with 100 mites/ ear. The first group was designated the positive control group and was not treated. The second and third groups were treated with doramectin 200 and 400 μg/kg bw, respectively. Groups 4 and 5 were treated by dressing with ivermectin in one dose and 2 doses with a 1 week interval. After the therapy, all rabbits were examined microscopically on the 7th, 14th, and 28th day post treatment and the number of live mites (larvae, nymphs, and adults) on each rabbit was counted at the end of the experiment (28th day). The results showed that the rabbits treated subcutaneously with doramectin at a single dose of 200 μg /kg bw showed a very low effect, although there was significant improvement when the dose was doubled to 400 μg /kg bw, with the number of mites counted decreasing significantly. Rabbits treated topically with ivermectin spot-on, a single dose or 2 doses, showed great improvement of the lesion: the number of mites was reduced to zero. In conclusion, this work showed that ivermectin spot-on applied locally on infested ears proves to be more effective against P. cuniculi than doramectin injected subcutaneously. Further trials on ear mange therapeutics in rabbits are to be encouraged. |
| Databáze: | OpenAIRE |
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