Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency
| Autor: | Ann F. Chambers, Alan B. Tuck, George N. Naumov, Sharon A. Vantyghem |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Oncology
isolated tumour cells medicine.medical_specialty Pathology Cell Survival Green Fluorescent Proteins in vivo videomicroscopy Breast Neoplasms Chick Embryo Review Biology Transfection Metastasis Mice Breast cancer Surgical oncology Cell Movement Computer Systems Genes Reporter Internal medicine medicine Biomarkers Tumor Animals Humans Clinical significance Neoplasm Metastasis Cell Line Transformed metastatic inefficiency Microscopy Video Cancer Mammary Neoplasms Experimental 3T3 Cells Fibroblasts medicine.disease Neoplastic Cells Circulating Microspheres Neoplasm Proteins Rats Luminescent Proteins tumour dormancy medicine.anatomical_structure Liver Lymphatic Metastasis Experimental pathology Female Lymph Bone marrow micrometastases |
| Zdroj: | Breast Cancer Research : BCR |
| ISSN: | 1465-5411 |
| Popis: | Recent technological advances have led to an increasing ability to detect isolated tumour cells and groups of tumour cells in patients' blood, lymph nodes or bone marrow. However, the clinical significance of these cells is unclear. Should they be considered as evidence of metastasis, necessitating aggressive treatment, or are they in some cases unrelated to clinical outcome? Quantitative experimental studies on the basic biology of metastatic inefficiency are providing clues that may help in understanding the significance of these cells. This understanding will be of use in guiding clinical studies to assess the significance of isolated tumour cells and micrometastases in cancer patients. |
| Databáze: | OpenAIRE |
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