A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana
| Autor: | M. J. Ramirez-Sierra, W G Chalé-Balboa, Maria del Rosario García-Miss, Mirza Mut-Martín, Eric Dumonteil |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Veterinary (miscellaneous) Leishmania mexicana Protozoan Proteins Leishmaniasis Cutaneous Hamster Biology DNA vaccination lcsh:Infectious and parasitic diseases Mice Cricetinae vaccine parasitic diseases Vaccines DNA medicine Animals lcsh:RC109-216 N-Glycosyl Hydrolases leishmaniasis Glycoproteins Sex Characteristics Kinetoplastida Leishmaniasis medicine.disease biology.organism_classification Leishmania Virology hamster Vaccination Infectious Diseases Insect Science Female Immunization Animal Science and Zoology Parasitology Nucleoside |
| Zdroj: | Parasite, Vol 16, Iss 3, Pp 227-230 (2009) |
| ISSN: | 1776-1042 |
| Popis: | Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA vaccine to induce protection in golden hamsters. Male hamsters were more susceptible to infection by Leishmania mexicana than females. Following immunization with two doses of the DNA vaccine, only females resulted protected while males developed normal lesions. |
| Databáze: | OpenAIRE |
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