A Versatile and Scalable Strategy to Discrete Oligomers
| Autor: | Michael C. Hawker, Will R. Gutekunst, Sang-Ho Lee, Luke A. Connal, Mitchell D. Nothling, Alaina J. McGrath, Youli Li, Abigail S. Knight, Allison Abdilla, Bernhard V. K. J. Schmidt, Austin S. Abrams, Jing M. Ren, Jimmy Lawrence, Carolin Fleischmann, Paul G. Clark, Craig J. Hawker |
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| Rok vydání: | 2016 |
| Předmět: |
Polymers
Thin layer Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Oligomer Article Catalysis Small Molecule Libraries chemistry.chemical_compound Colloid and Surface Chemistry Chromatography Extramural Reproducibility of Results General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Monomer chemistry Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Scalability Chromatography Gel Chromatography Thin Layer 0210 nano-technology |
| Zdroj: | Journal of the American Chemical Society. 138:6306-6310 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | A versatile strategy is reported for the multigram synthesis of discrete oligomers from commercially available monomer families, e.g., acrylates, styrenics, and siloxanes. Central to this strategy is the identification of reproducible procedures for the separation of oligomer mixtures using automated flash chromatography systems with the effectiveness of this approach demonstrated through the multigram preparation of discrete oligomer libraries (Đ = 1.0). Synthetic availability, coupled with accurate structural control, allows these functional building blocks to be harnessed for both fundamental studies as well as targeted technological applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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