The Role of Inflammation on Vitamin D Levels in a Cohort of Pediatric Patients With Inflammatory Bowel Disease
| Autor: | Alessandra Vitale, F.P. Giugliano, Annamaria Staiano, Massimo Martinelli, S. Cenni, Caterina Strisciuglio, Grazia Cirillo, Erasmo Miele, Emanuele Miraglia del Giudice, Carlo Tolone, Laura Perrone |
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| Přispěvatelé: | Strisciuglio, Caterina, Cenni, Sabrina, Giugliano, Francesca Paola, Miele, Erasmo, Cirillo, Grazia, Martinelli, Massimo, Vitale, Alessandra, Tolone, Carlo, Staiano, Annamaria, Miraglia Del Giudice, Emanuele, Perrone, Laura, Giudice, Emanele Miraglia Del, Perrone, Lura |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vitamin Male medicine.medical_specialty Adolescent Inflammation Activity index Inflammatory bowel disease Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Vitamin D and neurology medicine Humans In patient Prospective Studies Vitamin D Prospective cohort study Child business.industry Vitamin D-Binding Protein medicine.disease Inflammatory Bowel Diseases Vitamin D Deficiency 030104 developmental biology C-Reactive Protein chemistry Child Preschool Pediatrics Perinatology and Child Health Cohort 030211 gastroenterology & hepatology Female medicine.symptom business Biomarkers |
| Popis: | OBJECTIVES Existing studies usually do not measure the free vitamin D in pediatric patients with inflammatory bowel disease (IBD) and not consider the effect of inflammation on vitamin D levels. The aim of our study was to evaluate the concentrations of vitamin D-binding protein (VDBP), total and free 25-hydroxyvitamin-D (25(OH)D), and to correlate these values with the disease activity markers. METHODS Newly diagnosed children with IBD and a group of healthy controls (HCs) were enrolled. VDBP and total and free 25(OH)D levels were measured by enzyme-linked immunosorbent assay and compared using the Student t test. In each patient with IBD, the activity scores of disease and the main inflammation markers were correlated to total and free 25(OH)D levels. C-reactive protein was also measured in the control group, and it was related to VDBP by a linear regression test for all the groups. RESULTS Fifty-one consecutive children were enrolled: IBD = 33, HC = 18. Levels of total 25(OH)D were higher in HC than in patients with IBD (P = 0.01). The free/total 25(OH)D ratio was, however, higher in patients with IBD compared to HC (P |
| Databáze: | OpenAIRE |
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