Electrochemotherapy in the treatment of cutaneous metastases from breast cancer: a multicenter cohort analysis
| Autor: | A Santoriello, M Renne, Carlo Cabula, Roberto Agresti, Pietro Curatolo, Massimiliano D’Aiuto, Antonio Bonadies, Riccardo Bussone, Sara Valpione, Michele Guida, Nicola Solari, Luca Giovanni Campana, Gretha Grilz, M De Laurentiis, Sara Galuppo, L De Meo, Tommaso Fabrizio |
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| Přispěvatelé: | Cabula, C, Campana, L. G, Grilz, G, Galuppo, S, Bussone, R, De Meo, L, Bonadies, A, Curatolo, P, DE LAURENTIIS, Michelino, Renne, M, Valpione, S, Fabrizio, T, Solari, N, Guida, M, Santoriello, A, D'Aiuto, M, Agresti, R. |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Electrochemotherapy Skin Neoplasms Receptor ErbB-2 Cohort Studies chemistry.chemical_compound Surgical oncology Antineoplastic Combined Chemotherapy Protocols bleomycin Carcinoma Ductal Breast Follow up studies Electrochemotherapy Cutaneous Metastases Breast Cancer Hematology Middle Aged Prognosis Receptors Estrogen Female Receptors Progesterone Breast Neoplasm Human Cohort study medicine.medical_specialty Prognosi Breast Neoplasms Breast Oncology Bleomycin behavioral disciplines and activities Follow-Up Studie breast cancer Breast cancer Internal medicine mental disorders Biomarkers Tumor Carcinoma medicine Humans Neoplasm Invasiveness electrochemotherapy breast cancer chest wall recurrence bleomycin Aged Neoplasm Staging Neoplasm Invasivene Antineoplastic Combined Chemotherapy Protocol business.industry chest wall recurrence medicine.disease chemistry Progesterone metabolism Surgery Cohort Studie business Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology |
| ISSN: | 0923-7534 |
| Popis: | Background The management of breast cancer (BC) skin metastases represents a therapeutic challenge. Electrochemotherapy (ECT) combines the administration of bleomycin with temporary permeabilization induced by locally administered electric pulses. Preliminary experience with ECT in BC patients is encouraging. Methods A total of 125 patients with BC skin metastases who underwent ECT between 2010 and 2013 were enrolled onto a multicenter retrospective cohort study. The treatment was administered following the European Standard Operative Procedures of Electrochemotherapy. Tumor response was clinically assessed adapting the Response Evaluation Criteria in Solid Tumors, and toxicity was evaluated according to Common Terminology Criteria for Adverse Events 4.0. Cox regression analysis was used to identify predictive factors. Results Response was evaluable in 113 patients for 214 tumors (median 1 per patient, range 1–3). The overall response rate after 2 months was 90.2 %, while the complete response (CR) rate was 58.4 %. In multivariate analysis, small tumor size (P |
| Databáze: | OpenAIRE |
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