The impact of donor insemination on the risk of preeclampsia: a systematic review and meta-analysis
| Autor: | Ivan Solà, Mario Brassesco, Alejandro Saavedra Tascón, Miguel A. Checa, Radhanari Jimenéz, Mireia González-Comadran, Ramon Carreras, Julio Urresta Avila |
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| Rok vydání: | 2014 |
| Předmět: |
Gestational hypertension
Infertility Male endocrine system medicine.medical_specialty Preeclampsia Pre-Eclampsia Pregnancy Risk Factors medicine Humans reproductive and urinary physiology Insemination Artificial Homologous Gynecology urogenital system business.industry Coitus Obstetrics and Gynecology Odds ratio Hypertension Pregnancy-Induced medicine.disease Sperm Spermatozoa Tissue Donors Reproductive Medicine Meta-analysis Insemination Artificial Heterologous Observational study Female business Donor sperm |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 182 |
| ISSN: | 1872-7654 |
| Popis: | A systematic review and meta-analysis were performed to evaluate whether women who conceive with donor sperm have an increased risk of preeclampsia compared with those who use their partner's sperm. Studies that compared women who were impregnated by donor and partner sperm were included. The main outcomes assessed were preeclampsia and gestational hypertension rates. Altogether, 10,898 women (2342 pregnancies by donor sperm versus 8556 by the partner's sperm) were included from seven observational studies. Conception using donor sperm was associated with an increased risk of preeclampsia (odds ratio [OR] 1.63, 95% CI 1.36-1.95) compared with using a partner's sperm. No difference was observed in the risk of gestational hypertension (OR 0.94, 95% CI 0.43-2.03). In conclusion, pregnancies achieved by donor sperm significantly increase the risk of preeclampsia, although the underlying mechanisms remain unclear. Additional studies are required to confirm these findings. |
| Databáze: | OpenAIRE |
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