The Use of Hyperbaric Oxygen for Preservation of Free Flaps
| Autor: | Michael J. Im, Brent C. Birely, Paul N. Manson, Yolanda J. Tai, John E. Hoopes |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Xanthine Oxidase medicine.medical_specialty Necrosis chemistry.chemical_element Glucosephosphate Dehydrogenase Oxygen Surgical Flaps chemistry.chemical_compound Hexokinase medicine Animals Xanthine oxidase Hypoxanthine Hyperbaric Oxygenation Groin Tissue Preservation business.industry Graft Survival Glyceraldehyde-3-Phosphate Dehydrogenases Rats Inbred Strains Rats Surgery Transplantation medicine.anatomical_structure chemistry Hypoxanthines Anesthesia Room air distribution medicine.symptom business |
| Zdroj: | Annals of Plastic Surgery. 28:284-287 |
| ISSN: | 0148-7043 |
| DOI: | 10.1097/00000637-199203000-00016 |
| Popis: | The effects of hyperbaric oxygen (HBO) during tissue preservation on flap survival have been investigated in free flaps in rats. Groin skin flaps were harvested, stored in either room air or HBO (100% oxygen at 2.9 atm absolute) at 23 degrees C for 18 hours, and transplanted to the contralateral groin. Free flaps exhibit a high incidence of complete necrosis in the room air control. The survival of free flaps stored under HBO increased from 10% to 60% (p less than 0.05) after 18 hours of preservation. Skin flaps exhibited an increase in tissue hypoxanthine by 3.6-fold normal after 18 hours of storage in room air. HBO preservation prevented the accumulation of hypoxanthine and inhibited xanthine oxidase. Inhibition of the xanthine oxidase system may be one of the mechanisms of improved success of skin flap transplantation. |
| Databáze: | OpenAIRE |
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