Synthesis and biological properties of thiazole-analogues of pyochelin, a siderophore of Pseudomonas aeruginosa
| Autor: | Isabelle J. Schalk, Gaëtan L.A. Mislin, Freddy Rivault, Françoise Hoegy, Didier Rognan, Sabrina Noël |
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| Přispěvatelé: | Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Innovation Thérapeutique (LIT), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC) |
| Rok vydání: | 2013 |
| Předmět: |
Siderophore
Iron Clinical Biochemistry Pharmaceutical Science Siderophores Receptors Cell Surface [CHIM.THER]Chemical Sciences/Medicinal Chemistry 010402 general chemistry medicine.disease_cause 01 natural sciences Biochemistry chemistry.chemical_compound Phenols Biological property Drug Discovery medicine Thiazole Molecular Biology Iron uptake Binding Sites biology Molecular Structure 010405 organic chemistry Pseudomonas aeruginosa Organic Chemistry Transporter biology.organism_classification 0104 chemical sciences Thiazoles chemistry Molecular Medicine Bacterial outer membrane Bacteria Bacterial Outer Membrane Proteins |
| Zdroj: | Bioorganic and Medicinal Chemistry Letters Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (1), pp.132-135. ⟨10.1016/j.bmcl.2013.11.054⟩ |
| ISSN: | 1464-3405 0960-894X |
| DOI: | 10.1016/j.bmcl.2013.11.054⟩ |
| Popis: | Pyochelin is a siderophore common to all strains of Pseudomonas aeruginosa utilized by this Gram-negative bacterium to acquire iron(III). FptA is the outer membrane transporter responsible of ferric-pyochelin uptake in P. aeruginosa. We describe in this Letter the synthesis and the biological properties (55Fe uptake, binding to FptA) of several thiazole analogues of pyochelin. Among them we report in this Letter the two first pyochelin analogues able to bind FptA without promoting any iron uptake in P. aeruginosa. |
| Databáze: | OpenAIRE |
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