Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation
| Autor: | Thangarasu Silambarasan, Subramanian Kumar, Santosh K. Mishra, Boobalan Raja, Murugesan Saravanakumar, Jeganathan Manivannan, Pichavaram Prahalathan |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Lipid Peroxides Antioxidant medicine.medical_treatment Administration Oral Medicine (miscellaneous) Ascorbic Acid Vascular Remodeling Pharmacology medicine.disease_cause Cardiovascular System Thiobarbituric Acid Reactive Substances Antioxidants Lipid peroxidation chemistry.chemical_compound Oral administration Vegetables medicine Animals Vitamin E Rats Wistar Aorta Vanillic Acid chemistry.chemical_classification Glutathione Peroxidase Nutrition and Dietetics Dose-Response Relationship Drug Vitamin C Superoxide Dismutase Glutathione peroxidase Catalase Ascorbic acid Glutathione Rats Disease Models Animal Oxidative Stress NG-Nitroarginine Methyl Ester Biochemistry chemistry Cardiovascular Diseases Fruit Hypertension Lipid Peroxidation Oxidative stress |
| Zdroj: | British Journal of Nutrition. 114:1385-1394 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114515003086 |
| Popis: | In our previous studies, veratric acid (VA) shows beneficial effect on hypertension and its associated dyslipidaemia. In continuation, this study was designed to investigate the effect of VA, one of the major benzoic acid derivatives from vegetables and fruits, on cardiovascular remodelling in hypertensive rats, primarily assessed by functional studies using Langendorff isolated heart system and organ bath system. Hypertension was induced in male albino Wistar rats by oral administration ofNω-nitro-l-arginine methyl ester hydrochloride (l-NAME) (40 mg/kg body weight (b.w.)) in drinking water for 4 weeks. VA was orally administered at a dose of 40 mg/kg b.w.l-NAME-treated rats showed impaired cardiac ventricular and vascular function, evaluated by Langendorff isolated heart system and organ bath studies, respectively; a significant increase in the lipid peroxidation products such as thiobarbituric acid-reactive substances and lipid hydroperoxides in aorta; and a significant decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase and levels of GSH, vitamin C and vitamin E in aorta. Fibrotic remodelling of the aorta and heart were assessed by Masson’s Trichrome staining and Van Gieson’s staining, respectively. In addition,l-NAME rats showed increased heart fibronectin expression assessed by immunohistochemical analysis. VA supplementation throughout the experimental period significantly normalised cardiovascular function, oxidative stress, antioxidant status and fibrotic remodelling of tissues. These results of the present study conclude that VA acts as a protective agent against hypertension-associated cardiovascular remodelling. |
| Databáze: | OpenAIRE |
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