Effect of Trilostane and Mitotane on Aldosterone Secretory Reserve in Dogs with Pituitary-Dependent Hyperadrenocorticism
| Autor: | L.E. Reid, Robert J. Kemppainen, Hollie P. Lee, Linda G. Martin, Cynthia R. Ward, T.C. Donovan, J.C. Lurye, Ellen N. Behrend |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Hydrocortisone Sodium Vetoryl chemistry.chemical_element Stimulation Trilostane Decreased aldosterone Basal (phylogenetics) chemistry.chemical_compound Dogs Internal medicine medicine Animals Mitotane Dog Diseases Pituitary ACTH Hypersecretion Aldosterone General Veterinary business.industry Dihydrotestosterone Cushing's disease Lysodren medicine.disease Standard Articles Endocrinology chemistry Pituitary‐dependent hyperadrenocorticism Potassium Original Article Female business medicine.drug |
| Zdroj: | Journal of Veterinary Internal Medicine |
| ISSN: | 0891-6640 |
| Popis: | Background Maximal aldosterone secretion in healthy dogs occurs 30 minutes postadrenocorticotropin (ACTH; 5 μg/kg IV) stimulation. The effect of trilostane and mitotane on aldosterone at that time is unknown. Objectives To assess the effect of trilostane and mitotane in dogs with pituitary-dependent hyperadrenocorticism on aldosterone secretory reserve. To determine if aldosterone concentration correlates with electrolyte concentrations. Animals Serum collected from 79 client-owned dogs and 33 stored samples. Methods Client-owned dogs had ACTH stimulation tests with cortisol concentrations measured at 0 and 60 minutes and aldosterone concentrations measured at 0, 30, and 60 minutes. Stored samples had aldosterone concentrations measured at 0 and 60 minutes. Ten historical clinically healthy controls were included. All had basal sodium and potassium concentrations measured. Results The aldosterone concentrations in the mitotane- and trilostane-treated dogs at 30 and 60 minutes post-ACTH were significantly lower than in clinically healthy dogs; no significant difference was detected in aldosterone concentration between 30 and 60 minutes in treated dogs. However, a significantly higher percentage of dogs had decreased aldosterone secretory reserve detected at 30 minutes than at 60 minutes. At 30 minutes, decreased secretory reserve was detected in 49% and 78% of trilostane- and mitotane-treated dogs, respectively. No correlation was detected between aldosterone and serum electrolyte concentrations. Conclusions and Clinical Importance Decreased aldosterone secretory reserve is common in trilostane- and mitotane-treated dogs; it cannot be predicted by measurement of serum electrolyte concentrations. Aldosterone concentration at 30 minutes post-ACTH stimulation identifies more dogs with decreased aldosterone secretory reserve than conventional testing at 60 minutes. |
| Databáze: | OpenAIRE |
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