Antibodies against fetal brain in sera of mothers with autistic children
| Autor: | Christina M. Morris, Pam K. Gillin, Stephen O. Crawford, Harvey S. Singer, Colin D. Gause, Andrew W. Zimmerman |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Isoantigens medicine.medical_specialty Immunology Mothers Antibodies Heterophile Nerve Tissue Proteins medicine.disease_cause Autoimmunity Species Specificity Antigen Isoantibodies Pregnancy Internal medicine Glial Fibrillary Acidic Protein medicine Animals Humans Immunology and Allergy Autistic Disorder Maternal-Fetal Exchange Aged Autoantibodies Neurons Fetus biology Brain-Derived Neurotrophic Factor Brain nutritional and metabolic diseases Myelin Basic Protein Middle Aged medicine.disease Rats Myelin basic protein Parity Endocrinology Neurology Immunoglobulin G biology.protein Autism Female Neurology (clinical) Birth Order Antibody Psychology Developmental regression |
| Zdroj: | Journal of Neuroimmunology. 194:165-172 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2007.11.004 |
| Popis: | Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates human and rodent fetal and adult brain tissues, GFAP, and MBP. MCAD had significantly more individuals with Western immunoblot bands at 36 kDa in human fetal and rodent embryonic brain tissue. The density of bands was greater in fetal brain at 61 kDa. MCAD plus developmental regression had greater reactivity against human fetal brain at 36 and 39 kDa. Data support a possible complex association between genetic/metabolic/environmental factors and the placental transfer of maternal antibodies in autism. |
| Databáze: | OpenAIRE |
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