Factors associated with relapse-free survival after neoadjuvant chemotherapy for breast cancer at a safety net medical center
| Autor: | Tejas Manchandia, Elizabeth Vazquez, David S. Hong, Rachel E. Sargent, Maria Nelson, Alicia M. Terando, Pulin Sheth, Azadeh Carr, Janice Lu, Stephen F. Sener, Irene Kang |
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| Rok vydání: | 2022 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Relapse free survival Disease-Free Survival Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Retrospective analysis Humans skin and connective tissue diseases Complete response Retrospective Studies Chemotherapy business.industry General Medicine Prognosis medicine.disease Neoadjuvant Therapy Chemotherapy Adjuvant Female Surgery Neoplasm Recurrence Local business |
| Zdroj: | The American Journal of Surgery. 223:539-542 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2021.11.017 |
| Popis: | Background This study was designed to assess prognostic factors associated with relapse-free survival (RFS) after neoadjuvant chemotherapy (NAC) for breast cancer. Methods A single-institution retrospective analysis was performed including clinical, radiographic, and pathologic parameters for all breast cancer patients treated with NAC from 2015 to 2018. All patients had pre-and post-NAC MRI. Results For 102 patients, median follow-up was 47.4 months, and the five-year RFS was 74%. The 41 (40%) patients who achieved pathologic complete response (pCR) after NAC had a significantly higher five-year RFS than the 61 not achieving pCR. For 31 patients with triple-negative cancers, the five-year RFS was significantly higher in those achieving pCR vs. no pCR. The 44 (43%) patients who achieved radiographic complete response (rCR) after NAC had similar five-year RFS to the 58 (57%) not achieving rCR. Conclusion pCR, node-negativity after NAC, and triple-negative subtype were prognostic factors associated with relapse-free survival after NAC. |
| Databáze: | OpenAIRE |
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