Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China
| Autor: | Yanfen Nong, Jihong Liu, Fengxiu Ouyang, Susan A. Korrick, Qiurong Chen, Xiaoyun Zeng, Yunfeng Zou, Eva Trinh, Sarah E. Rothenberg, Hua Nong, Jian Shen, Fred J. Biasini |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Rural Population 0301 basic medicine China Cross-sectional study Science Models Neurological Mothers Microbial communities Gut flora Sutterella Bayley Scales of Infant Development Article Feces Young Adult 03 medical and health sciences Child Development 0302 clinical medicine Interquartile range RNA Ribosomal 16S Humans Prospective Studies Psychomotor learning Multidisciplinary biology Cognitive neuroscience biology.organism_classification Confidence interval Gastrointestinal Microbiome Cross-Sectional Studies 030104 developmental biology Child Preschool Multivariate Analysis Medicine Female Alpha diversity Microbiome 030217 neurology & neurosurgery Neuroscience Follow-Up Studies Maternal Age Demography |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-86761-7 |
| Popis: | We investigated cross-sectional associations between children’s neurodevelopment and their gut microbiota composition. Study children (36 months of age) lived in rural China (n = 46). Neurodevelopment was assessed using the Bayley Scales of Infant Development, 2nd Edition, yielding the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI). Children's gut microbiota was assessed using 16S rRNA gene profiling. Microbial diversity was characterized using alpha diversity patterns. Additionally, 3 coabundance factors were determined for the 25 most abundant taxa. Multivariable linear regression models were constructed to examine the relationships between Bayley scores (MDI and PDI) and children's gut microbiota. In adjusted models, MDI and PDI scores were not associated with alpha diversity indices. However, in adjusted models, MDI and PDI scores were positively associated with the first coabundance factor, which captured positive loadings for the genera Faecalibacterium, Sutterella, and Clostridium cluster XIVa. For an interquartile range increase in the first coabundance factor, MDI scores increased by 3.9 points [95% confidence interval (CI): 0, 7.7], while PDI scores increased by 8.6 points (95% CI 3.1, 14). Our results highlight the potential for gut microbial compositional characteristics to be important correlates of children's Bayley Scales performance at 36 months of age. |
| Databáze: | OpenAIRE |
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