Random nucleotide substitutions in primate nonfunctional gene for L-gulono-gamma-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis
| Autor: | Yuriko Ohta, Morimitsu Nishikimi |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pseudogene
Molecular Sequence Data Biophysics Ascorbic Acid Biology medicine.disease_cause Biochemistry Exon Sequence Homology Nucleic Acid L-gulonolactone oxidase medicine Animals Humans Nucleotide Molecular Biology Gene chemistry.chemical_classification Genetics Oxidase test Mutation Base Sequence Nucleic acid sequence DNA chemistry biology.protein L-Gulonolactone Oxidase Sugar Alcohol Dehydrogenases |
| Zdroj: | Biochimica et biophysica acta. 1472(1-2) |
| ISSN: | 0006-3002 |
| Popis: | Humans and other primates have no functional gene for L-gulono-gamma-lactone oxidase that catalyzes the last step of L-ascorbic acid biosynthesis. The 164-nucleotide sequence of exon X of the gene was compared among human, chimpanzee, orangutan, and macaque, and it was found that nucleotide substitutions had occurred at random throughout the sequence with a single nucleotide deletion, indicating that the primate L-gulono-gamma-lactone oxidase genes are a typical example of pseudogene. |
| Databáze: | OpenAIRE |
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