The effect of diabetes mellitus and end-stage renal disease on the number of CD34+ cells in the blood
Autor: | Ismail Kocyigit, Yavuz Köker, Ilker Altun, Serdar Sivgin, Cigdem Pala, Bulent Eser, Fatih Tanriverdi, Fatih Kurnaz, Mustafa Cetin, Ferhan Elmali, Leylagül Kaynar |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Renal function Antigens CD34 Kidney Function Tests Gastroenterology Nephropathy End stage renal disease Diabetic nephropathy chemistry.chemical_compound Diabetes mellitus Internal medicine Diabetes Mellitus medicine Humans Dialysis Aged Creatinine medicine.diagnostic_test business.industry Complete blood count Hematology General Medicine Middle Aged Hematopoietic Stem Cells medicine.disease eye diseases Endocrinology chemistry Kidney Failure Chronic Female business Biomarkers Glomerular Filtration Rate |
Zdroj: | Annals of Hematology. 92:1189-1194 |
ISSN: | 1432-0584 0939-5555 |
Popis: | The aim of this study was to investigate the effect of end-stage renal disease (ESRD) and diabetes mellitus (DM) on the number of stem cells in the peripheral blood. Sixty-two patients diagnosed with ESRD who had not received dialysis previously, 25 patients with a diagnosis of DM without nephropathy, and 21 healthy volunteers were included in the study. The group diagnosed with ESRD was divided into two groups. The first group (DM-CRD) consisted of 28 patients with DM who had developed chronic renal disease (CRD). The second group (NON-DM-CRD) consisted of 34 patients without DM who had CRD by etiology. The routine complete blood count, renal function, and number of CD34+ cells were determined for all of those involved in the study. The microalbumin/creatinine levels were measured, and glomerular filtration rates were calculated in all patients. The number of CD34+ cells was found to be significantly lower in the DM control group and DM-CRD group compared with the healthy group. No statistically significant difference was found between the NON-DM-CRD and the healthy control group. There was a moderate negative correlation between the ratio of microalbumin/creatinine and the number of CD34+ cells. A significant reduction in the number of CD34+ cells was shown in subjects with DM and ESRD caused by diabetic nephropathy. |
Databáze: | OpenAIRE |
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