Analiza leptina,adiponectina i polimorfizma gena za adiponectin i receptora za leptin u pretile djece i adolescenata
| Autor: | Daniela Šupe Domić, Ivana Unić Šabašov, Lada Stanišić, Sunčana Janković, Milena Nadrčić, Antonela Matana, Esma Čečuk-Jeličić, Irena Drmić Hofman |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Hrvatski časopis zdravstvenih znanosti Volume 1 Issue 1 |
| ISSN: | 2787-4761 |
| DOI: | 10.48188/hczz.3.1.3 |
| Popis: | Background: The aim of this study was to determine serum levels of leptin and adiponectin of obese children to identify the influence of leptin receptor gene polymorphisms on leptin resistance and leptin levels, as well as the association between the polymorphisms of adiponectin gene and adiponectin levels.Materials and methods: A case-control study comparing a study group of 74 obese children (age 13.34±2.60 years) to a normal weight-age matched (age 13.39±2.64 years) control group of 69 children. In both groups, body mass index (BMI) and waist/hip circumference, systolic and diastolic blood pressure were measured. Also, the leptin and adiponectin levels, as well as glucose and lipid metabolism parameters, and highly sensitive C-reactive protein (hs-CRP) were measured. Insulin sensitivity was evaluated using fasting insulinemia and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). All subjects were tested for gene-tic polymorphisms in LEPRQ223R (rs1137101), ADIPOQ G276T (rs1501299) and ADIPOT45G (rs2241766).Results: The phenotypes of the obese children study group were significantly higher than in the control group in weight, BMI, waist/hip circumferences and systolic blood pressure (SBP) (P |
| Databáze: | OpenAIRE |
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