Carotid Artery Longitudinal Displacement Predicts 1-Year Cardiovascular Outcome in Patients With Suspected Coronary Artery Disease

Autor: Sara Svedlund, Charlotte Eklund, Milan Lomsky, Per Robertsson, Li-Ming Gan
Rok vydání: 2011
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
Carotid Artery
Common
Coronary Artery Disease
Kaplan-Meier Estimate
Risk Assessment
Disease-Free Survival
Coronary artery disease
Myocardial perfusion imaging
Coronary circulation
Predictive Value of Tests
Risk Factors
Coronary Circulation
medicine.artery
Odds Ratio
medicine
Humans
cardiovascular diseases
Common carotid artery
Survival rate
Aged
Proportional Hazards Models
Ultrasonography
Aged
80 and over
Sweden
Tomography
Emission-Computed
Single-Photon
Analysis of Variance
Chi-Square Distribution
medicine.diagnostic_test
Vascular disease
business.industry
Myocardial Perfusion Imaging
Middle Aged
Prognosis
medicine.disease
Survival Rate
medicine.anatomical_structure
Cardiovascular Diseases
Predictive value of tests
Disease Progression
Female
Radiology
Cardiology and Cardiovascular Medicine
business
Mace
Compliance
Zdroj: Arteriosclerosis, Thrombosis, and Vascular Biology. 31:1668-1674
ISSN: 1524-4636
1079-5642
Popis: Objective— Total longitudinal displacement (tLoD) of the common carotid artery can be measured using the ultrasound-based velocity vector imaging (VVI) technique. This study aimed to investigate clinical correlates and the possible predictive value of tLoD for cardiovascular outcome. Methods and Results— Four hundred forty-one patients referred for myocardial perfusion scintigraphy examination for suspected coronary artery disease were recruited and underwent VVI-assisted tLoD measurement. Patients were followed up with regard to major adverse cardiovascular event (MACE) 1 year later. Low tLoD (≤0.055 mm) was associated with greater clinically determined myocardial ischemia ( P 0.055 mm) predicted 1-year event-free survival ( P P =0.03). Finally, low tLoD provided additional predictive value in subjects with increased intima-media thickness. Conclusion— VVI-derived tLoD seems to reflect cardiovascular status and predicts short-term event-free survival in medium- to high-risk patients. Finally, tLoD per se or in combination with intima-media thickness measurement may be a novel cardiovascular surrogate biomarker.
Databáze: OpenAIRE
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