Rifaximin‐altered gut microbiota components associated with liver/neuropsychological functions in patients with hepatic encephalopathy: An exploratory data analysis of phase II/III clinical trials
| Autor: | Masatoshi Imamura, Naoya Murashima, Masaki Fujisawa, Tetsuya Mine, Takumi Kawaguchi, Mikio Yanase, Kiwamu Okita, Fumitaka Suzuki, Ikuya Sato, Hitoshi Yoshiji, Kazuyuki Suzuki |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class liver cirrhosis hepatic encephalopathy Antibiotics Veillonella Gut flora medicine.disease_cause Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine White blood cell Internal medicine Lactobacillus medicine Hepatic encephalopathy Hepatology biology Streptococcus business.industry Original Articles medicine.disease biology.organism_classification Rifaximin rifaximin Infectious Diseases medicine.anatomical_structure Cirrhosis chemistry 030220 oncology & carcinogenesis gut flora Original Article 030211 gastroenterology & hepatology business |
| Zdroj: | Hepatology Research |
| ISSN: | 1872-034X 1386-6346 |
| Popis: | AIMS Rifaximin (RFX), a non-systemic antibiotic, improves liver/neuropsychological functions in patients with hepatic encephalopathy (HE). We aimed to investigate the clinical profiles associated with gut bacterial loads using exploratory data analysis and the effects of RFX on the gut microbiota of patients with HE. METHODS We analyzed the data from 17 patients with HE who underwent fecal microbiota examination in phase II/III trials in Japan. Profiles associated with genera Streptococcus, Veillonella, and Lactobacillus loads were analyzed using classification and regression trees (CART). Changes in gut microbial consortia of seven patients with HE were then assessed 2 weeks after RFX treatment by principal component analysis. RESULTS In the CART, the first and second divergence variables for each higher bacterial load were as follows: (i) in Streptococcus, the number connection test-A ≥39.55 s and presence of portal-systemic shunt; (ii) in Veillonella, serum potassium levels |
| Databáze: | OpenAIRE |
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