Randomized feeding intervention in infants at high risk for celiac disease
| Autor: | Renata Auricchio, C.E. Hogen Esch, Anneli Ivarsson, Hein Putter, Eva Martínez-Ojinaga, Riccardo Troncone, E. Bravi, E. Hopman, M.L. Mearin, E. Mummert, Vincenzo Villanacci, Luigi Greco, Tunde Koltai, Jihane Romanos, A. Mocic Pavic, C. te Marvelde, Sanja Kolaček, Hania Szajewska, Sibylle Koletzko, Katharina J. Werkstetter, A. Chmielewska, Catharina A. Hartman, Frits Koning, Raanan Shamir, E. Stoopman, Judit Gyimesi, Gemma Castillejo, Isabel Polanco, Cisca Wijmenga, P. Crespo Escobar, Ilma Rita Korponay-Szabó, Carmen Ribes-Koninckx, Sabine L. Vriezinga |
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| Přispěvatelé: | Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Vriezinga, Sl, Auricchio, Renata, Bravi, E, Castillejo, G, Chmielewska, A, Crespo Escobar, P, Kola??ek, S, Koletzko, S, Korponay Szabo, Ir, Mummert, E, Polanco, I, Putter, H, Ribes Koninckx, C, Shamir, R, Szajewska, H, Werkstetter, K, Greco, Luigi, Gyimesi, J, Hartman, C, Hogen Esch, C, Hopman, E, Ivarsson, A, Koltai, T, Koning, F, Martinez Ojinaga, E, te Marvelde, C, Pavic, A, Romanos, J, Stoopman, E, Villanacci, V, Wijmenga, C, Troncone, Riccardo, Mearin, M. L. |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics AUTOIMMUNITY Biopsy HETERODIMER CHILDREN Gliadin Intestine Small Cumulative incidence Prospective Studies Prospective cohort study Child POPULATION chemistry.chemical_classification education.field_of_study Hazard ratio General Medicine Orvostudományok Breast Feeding Child Preschool NUTRITION Female HEALTH Dietary Proteins Risk medicine.medical_specialty Genotype Glutens Population QUESTIONNAIRE Placebo DIAGNOSIS Klinikai orvostudományok Double-Blind Method EPIDEMIC GTP-Binding Proteins HLA-DQ Antigens medicine Humans Protein Glutamine gamma Glutamyltransferase 2 education Pediatric gastroenterology Autoantibodies Proportional Hazards Models Transglutaminases business.industry Infant nutritional and metabolic diseases Gluten PREVENTION digestive system diseases Diet chemistry business Breast feeding celiac disease |
| Zdroj: | New England Journal of Medicine, 371(14), 1304-1315 NEW ENGLAND JOURNAL OF MEDICINE r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname New England Journal of Medicine, 371(14), 1304-1315. MASSACHUSETTS MEDICAL SOC |
| ISSN: | 0028-4793 |
| Popis: | BACKGROUNDA window of opportunity has been suggested for reducing the risk of celiac disease by introducing gluten to infants at 4 to 6 months of age.METHODSWe performed a multicenter, randomized, double-blind, placebo-controlled dietary-intervention study involving 944 children who were positive for HLA-DQ2 or HLA-DQ8 and had at least one first-degree relative with celiac disease. From 16 to 24 weeks of age, 475 participants received 100 mg of immunologically active gluten daily, and 469 received placebo. Anti-transglutaminase type 2 and antigliadin antibodies were periodically measured. The primary outcome was the frequency of biopsy-confirmed celiac disease at 3 years of age.RESULTSCeliac disease was confirmed by means of biopsies in 77 children. To avoid underestimation of the frequency of celiac disease, 3 additional children who received a diagnosis of celiac disease according to the 2012 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition diagnostic criteria (without having undergone biopsies) were included in the analyses (80 children; median age, 2.8 years; 59% were girls). The cumulative incidence of celiac disease among patients 3 years of age was 5.2% (95% confidence interval [CI], 3.6 to 6.8), with similar rates in the gluten group and the placebo group (5.9% [95% CI, 3.7 to 8.1] and 4.5% [95% CI, 2.5 to 6.5], respectively; hazard ratio in the gluten group, 1.23; 95% CI, 0.79 to 1.91). Rates of elevated levels of anti-transglutaminase type 2 and antigliadin antibodies were also similar in the two study groups (7.0% [95% CI, 4.7 to 9.4] in the gluten group and 5.7% [95% CI, 3.5 to 7.9] in the placebo group; hazard ratio, 1.14; 95% CI, 0.76 to 1.73). Breast-feeding, regardless of whether it was exclusive or whether it was ongoing during gluten introduction, did not significantly influence the development of celiac disease or the effect of the intervention.CONCLUSIONSAs compared with placebo, the introduction of small quantities of gluten at 16 to 24 weeks of age did not reduce the risk of celiac disease by 3 years of age in this group of high-risk children. (Funded by the European Commission and others; PreventCD Current Controlled Trials number, ISRCTN74582487.) |
| Databáze: | OpenAIRE |
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