Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan((R)) predicts the absence of significant liver fibrosis
| Autor: | Elke M G J de Jong, Josje Snoek, M.A.M. Berends, Robert J. de Knegt, J. Han van Krieken, Peter C.M. van de Kerkhof, Martijn G.H. van Oijen, Joost P.H. Drenth |
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| Přispěvatelé: | Gastroenterology & Hepatology, Oncology |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Age-related aspects of cancer [ONCOL 2] Genetics and epigenetic pathways of disease [NCMLS 6] Biopsy Liver fibrosis Population Membrane transport and intracellular motility [NCMLS 5] Auto-immunity transplantation and immunotherapy [N4i 4] Gastroenterology Translational research [ONCOL 3] Artificial Intelligence Internal medicine Psoriasis medicine Humans Molecular gastro-enterology and hepatology [IGMD 2] Translational research [CTR 3] education Molecular diagnosis prognosis and monitoring [UMCN 1.2] Aged Ultrasonography Chronic inflammation and autoimmunity [UMCN 4.2] education.field_of_study Hereditary cancer and cancer-related syndromes [ONCOL 1] Dose-Response Relationship Drug Hepatology medicine.diagnostic_test FibroTest business.industry Middle Aged medicine.disease Pathogenesis and modulation of inflammation [N4i 1] Methotrexate Genetic defects of metabolism [UMCN 5.1] Liver Liver biopsy Female Dermatologic Agents Hepatic fibrosis business Algorithms medicine.drug |
| Zdroj: | Liver International, 27(5), 639-645. Wiley-Blackwell Publishing Ltd Liver International, 27, 639-45 Liver international, 27(5), 639-645. Wiley-Blackwell Liver International, 27, 5, pp. 639-45 |
| ISSN: | 1478-3223 |
| DOI: | 10.1111/j.1478-3231.2007.01489.x |
| Popis: | Contains fulltext : 52778.pdf (Publisher’s version ) (Closed access) BACKGROUND: Methotrexate (MTX) use is associated with hepatic fibrosis in psoriasis patients. To monitor this serial liver biopsies were performed. The Fibroscan and the Fibrotest are two novel, non-invasive methods that might be able to assess MTX-induced hepatic fibrosis. AIM: Evaluating the accuracy and feasibility of the Fibroscan and Fibrotest to detect significant MTX-induced liver fibrosis in psoriasis patients. Methods: We assessed 24 psoriasis patients who had a recent liver biopsy during MTX use. The results from the Fibroscan and Fibrotest were compared with liver histology. RESULTS: Fibroscan values (n=20) ranged between 3.3 and 18.4 kPa (median value 6.4 kPa) and correctly identified 88% of the patients without significant liver fibrosis (Metavir score /=F2, Fibrotest >0.31). CONCLUSION: In this population, Fibrotest accurately predicted the presence of significant liver fibrosis while the Fibroscan accurately predicted the absence of significant liver fibrosis in MTX users. This suggests that a combination of Fibrotest and Fibroscan should prospectively be evaluated in monitoring and detecting significant MTX-induced liver fibrosis in psoriasis patients. |
| Databáze: | OpenAIRE |
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