Water Channels (Aquaporins) and Their Role for Postnatal Adaptation
| Autor: | Anita Aperia, Marina Zelenina, Sergey Zelenin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Time Factors
Period (gene) Aquaporin Biology Aquaporins Kidney Diffusion Mice Body Water Animals Humans Protein Isoforms Tissue Distribution Tissue distribution Lung Regulation of gene expression Water transport Cell Membrane Infant Newborn Brain Gene Expression Regulation Developmental Kidney metabolism Nephrons Anatomy Cell biology Animals Newborn Pediatrics Perinatology and Child Health Adaptation Homeostasis |
| Zdroj: | Pediatric Research. 57:47R-53R |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Birth is a transition from an underwater life in the uterus to a terrestrial life in a milieu where supply of water is limited. Rapid adaptation to the new environment is crucial for survival and health of infants. The discovery of a family of molecules-aquaporin (AQP) water channels-that are responsible for regulated water transport across cell membranes has made it possible to identify the molecular mechanisms behind the postnatal homeostatic adaptation and to better understand water imbalance-related disorders in infancy and childhood. Thirteen mammalian AQP isoforms have been identified, most of them having a unique tissue-specific pattern of expression. Most mammalian AQPs can be dynamically regulated, which makes them potential targets for the development of new drugs for diseases associated with disturbances in water homeostasis. This review deals with AQP in kidney, lung, and brain. Evidence is presented that AQPs are expressed in a specific age-dependent manner and that the timed expression of AQPs may have a crucial role during the early postnatal period. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|