Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke: Meta-Analysis of Five Randomized Controlled Trials with 3440 Patients
| Autor: | Gabriel Lopes Martins, Giulia Cioffi Nascimento, Michel Pompeu Barros de Oliveira Sá, Frederico Pires Vasconcelos Silva, Luiz de Albuquerque Pereira de Oliveira Neto, Ricardo Felipe de Albuquerque Lins, Gabriella Caroline Sales do Nascimento, Erik Everton da Silva Vieira, Karine Coelho Rodrigues, Ricardo de Carvalho Lima, Alexandre Motta de Menezes |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty Septal Occluder Device lcsh:Surgery Foramen Ovale Patent Review Article 030204 cardiovascular system & hematology Risk Assessment law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Vascular closure device Closure (psychology) Stroke Randomized Controlled Trials as Topic 030505 public health business.industry Atrial fibrillation lcsh:RD1-811 General Medicine medicine.disease lcsh:RC666-701 Meta-analysis Relative risk Patent foramen ovale Surgery 0305 other medical science Cardiology and Cardiovascular Medicine business Vascular Closure Devices Meta-Analysis |
| Zdroj: | Brazilian Journal of Cardiovascular Surgery v.33 n.1 2018 Brazilian Journal of Cardiovascular Surgery Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV) instacron:SBCCV Brazilian Journal of Cardiovascular Surgery, Vol 33, Iss 1, Pp 89-98 Brazilian Journal of Cardiovascular Surgery, Volume: 33, Issue: 1, Pages: 89-98, Published: FEB 2018 |
| Popis: | Objective: We aimed to determine whether patent foramen ovale closure reduces the risk of stroke, also assessing some safety outcomes. Introduction: The clinical benefit of closing a patent foramen ovale after a cryptogenic stroke has been an open question for several decades, so that it is necessary to review the current state of published medical data in this regard. Methods: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LI-LACS, Google Scholar and reference lists of relevant articles were searched for randomized controlled trials that reported any of the following outcomes: stroke, death, major bleeding or atrial fibrillation. Five studies fulfilled our eligibility criteria and included 3440 patients (1829 for patent foramen ovale closure and 1611 for medical therapy). Results: The risk ratio (RR) for stroke in the "device closure" group compared with the "medical therapy" showed a statistically significant difference between the groups, favouring the "device closure" group (RR 0.400; 95% CI 0.183-0.873, P=0.021). There was no statistically significant difference between the groups regarding the safety outcomes death and major bleeding, but we observed an increase in the risk of atrial fibrillation in the "device closure group (RR 4.000; 95% CI 2.262-7.092, P |
| Databáze: | OpenAIRE |
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