Synthesis Of Some Novel 1-(2-Naphthyl)-2-(Imidazol-1-Yl)Ethanone Oxime Ester Derivatives And Evaluation Of Their Anticonvulsant Activity
| Autor: | Mehmet Abdullah Alagöz, Ünsal Çalış, Burcu Sayoğlu, Sevim Dalkara, Arzu Karakurt |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_treatment
Compound 17 Motor Activity Neuropsychological Tests Mice Structure-Activity Relationship chemistry.chemical_compound Isomerism Seizures Oximes Drug Discovery medicine Animals Organic chemistry Alkyl Pharmacology chemistry.chemical_classification Electroshock Ester derivatives Aryl Organic Chemistry Imidazoles Esters General Medicine Naphazoline Oxime Anticonvulsant chemistry Anticonvulsants Nafimidone |
| Popis: | Twenty-three new oxime ester derivatives of nafimidone were synthesized with the prospect of potential anticonvulsant activities. MES and ScM tests were employed for their anticonvulsant activities and rotorod test for neurological deficits. Eighteen compounds were found to be protective against MES seizures. Alkyl (1-8) and arylalkyl (9,10) oxime ester derivatives were found to be more active than aryl oxime ester derivatives (11-23). Five compounds (2, 3, 7, 9, 10), which were protective at 0.5 h at the doses of 30 mg/kg and higher in MES test, showed the highest activity. Compound 17 was the most active one in ScM test at all dose levels at 4 h. (C) 2012 Elsevier Masson SAS. All rights reserved. |
| Databáze: | OpenAIRE |
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