Surveillance of daughter micronodule formation is a key factor for vaccine evaluation using experimental infection models of tuberculosis in Macaques
| Autor: | Isabel Nogueira, Martí Català, Andrew D. White, Sally A Sharpe, Jordi Bechini, Clara Prats, Cristina Vilaplana, Pere-Joan Cardona |
|---|---|
| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. BIOCOM-SC - Biologia Computacional i Sistemes Complexos |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Microbiology (medical)
Tuberculose--Recherche General Immunology and Microbiology macaque Bubble model pathology_pathobiology non-human primate Non-human primate Aerosol vaccination Computed tomography scanner Infectious Diseases bubble model computed tomography scanner tuberculosis Enginyeria agroalimentària::Ciències de la terra i de la vida::Microbiologia [Àrees temàtiques de la UPC] Immunology and Allergy Tuberculosis aerosol vaccination Tuberculosi--Patogènesi Molecular Biology BCG vaccine Macaque |
| Zdroj: | Pathogens Volume 12 Issue 2 Pages: 236 |
| Popis: | Tuberculosis (TB) is still a major worldwide health problem and models using non-human primates (NHP) provide the most relevant approach for vaccine testing. In this study, we analysed CT images collected from cynomolgus and rhesus macaques following exposure to ultra-low dose Mycobacterium tuberculosis (Mtb) aerosols, and monitored them for 16 weeks to evaluate the impact of prior intradermal or inhaled BCG vaccination on the progression of lung disease. All lesions found (2553) were classified according to their size and we subclassified small micronodules ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|