Bioresorbable scaffold — A magic bullet for the treatment of coronary artery disease?
| Autor: | Peter E. Penson, Peter P. Toth, Charles A. Simonton, Daniel Brie, Patrick W. Serruys, Maria-Corina Serban, Maciej Banach |
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| Rok vydání: | 2016 |
| Předmět: |
RM
medicine.medical_specialty Coronary Artery Disease 030204 cardiovascular system & hematology Prosthesis Design RS Coronary artery disease 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Internal medicine Absorbable Implants medicine Humans 030212 general & internal medicine Stent thrombosis Randomized Controlled Trials as Topic Neointimal hyperplasia Clinical Trials as Topic Interventional treatment business.industry medicine.disease Surgery Clinical trial Treatment Outcome Cardiology Stents Cardiology and Cardiovascular Medicine business Magic bullet Bioresorbable scaffold |
| Zdroj: | International Journal of Cardiology. 215:47-59 |
| ISSN: | 0167-5273 1874-1754 |
| Popis: | Today, drug-eluting metal stents are considered the gold standard for interventional treatment of coronary artery disease. While providing inhibition of neointimal hyperplasia, drug-eluting metal stents have many limitations such as the risk of late and very late stent thrombosis, restriction of vascular vasomotion and chronic local inflammatory reaction due to permanent implantation of a 'metallic cage', recognized as a foreign body. Bioresorbable scaffold stents (BRS) are a new solution, which is trying to overcome the limitation of the 'metallic cage'. This structure provides short-term scaffolding of the vessel and then disappears, leaving nothing behind. The purpose of this review is to present the theoretical rationale for the use of BRS and to outline the clinical outcomes associated with their use in terms of data obtained from RCTs, clinical trials, registries and real life use. We have also tried to answer all questions on this intervention based on available data, with a focus on ABSORB BVS (Abbott Vascular, Santa Clara, USA). We consider that this new technology can be the "magic bullet" to treat coronary artery disease. |
| Databáze: | OpenAIRE |
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