Creatinine- vs. cystatin C-based equations compared with 99mTcDTPA scintigraphy to assess glomerular filtration rate in chronic kidney disease
| Autor: | María S. Raña, Vicente Campolo-Girard, Hernán Trimarchi, Alexis Muryan, Diana Martino, Agostina Toscano, Mariano Forrester, Romina Iriarte, Pablo Young, Mirta Alonso, Fernando Lombi, Vanesa Pomeranz, Clara Fitzsimons |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urology Renal function Kidney Models Biological Severity of Illness Index chemistry.chemical_compound Young Adult Predictive Value of Tests Risk Factors Diabetes mellitus medicine Humans Prospective Studies Cystatin C Renal Insufficiency Chronic Radionuclide Imaging Aged Aged 80 and over Creatinine Analysis of Variance Proteinuria Chi-Square Distribution biology business.industry Kidney metabolism Middle Aged medicine.disease Cross-Sectional Studies chemistry Nephrology biology.protein Linear Models Technetium Tc 99m Pentetate Female medicine.symptom Radiopharmaceuticals business Body mass index Biomarkers Kidney disease Glomerular Filtration Rate |
| Zdroj: | Journal of nephrology. 25(6) |
| ISSN: | 1724-6059 |
| Popis: | BACKGROUND In chronic kidney disease (CKD), accurate estimation of the glomerular filtration rate (GFR) is mandatory. Gold standard methods for its estimation are expensive and time-consuming. We compared creatinine- versus cystatin C-based equations to measure GFR, employing (99m)Tc-DTPA scintigraphy as the gold standard. METHODS This was a prospective cross-sectional observational study including 300 subjects. CKD was defined according to K/DOQI guidelines, and patients were separated into groups: stage 1 (G1), n=26; stage 2 (G2), n=52; stage 3 (G3), n=90; stage 4 (G4), n=37; stage 5 (G5), n=60; and control group, n=35. Creatinine-based estimates were from 24-hour creatinine clearance using the Walser formula, Cockcroft-Gault, MDRD-4 and CKD-EPI; cystatin C equations used were Larsson, Larsson modified equation, Grubb and Hoek. RESULTS Age and body mass index were different among groups; proteinuria, hypertension, diabetes and primary glomerulopathies significantly increased as CKD worsened. In the global assessment, CKD-EPI and Hoek gave the highest correlations with (99m)Tc-DTPA: rho=0.826, p |
| Databáze: | OpenAIRE |
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