Structural integrity in subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease based on multicenter diffusion tensor imaging

Autor: Coraline D. Metzger, Josef Priller, Ruth Vukovich, Jens Wiltfang, Michael Wagner, Daniel Janowitz, Eike Jakob Spruth, Martina Buchmann, Ingo Kilimann, Frank Jessen, Martin Dyrba, Oliver Peters, Arturo Cardenas-Blanco, Klaus Fliessbach, Janna Rudolph, Anja Schneider, Katharina Brueggen, Stefan J. Teipel, Christoph Laske, Sandra Röske, Katharina Buerger, Annika Spottke, Emrah Düzel, Laura Dobisch, Felix Menne
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
physiopathology [Cognitive Dysfunction]
pathology [Cognitive Dysfunction]
diagnostic imaging [Cognitive Dysfunction]
Splenium
Corpus callosum
behavioral disciplines and activities
diagnostic imaging [White Matter]
White matter
pathology [Alzheimer Disease]
Diagnostic Self Evaluation
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
pathology [White Matter]
Internal medicine
Fractional anisotropy
Humans
Medicine
Cingulum (brain)
Cognitive Dysfunction
ddc:610
Longitudinal Studies
030212 general & internal medicine
Inferior longitudinal fasciculus
Cognitive decline
Aged
Aged
80 and over
business.industry
Middle Aged
White Matter
Diffusion Tensor Imaging
medicine.anatomical_structure
Neurology
Cardiology
Female
Neurology (clinical)
business
diagnostic imaging [Alzheimer Disease]
030217 neurology & neurosurgery
Diffusion MRI
Zdroj: Journal of neurology 266(10), 2465-2474 (2019). doi:10.1007/s00415-019-09429-3
ISSN: 1432-1459
0340-5354
DOI: 10.1007/s00415-019-09429-3
Popis: Subjective cognitive decline (SCD) can represent a preclinical stage of Alzheimer’s disease. Diffusion tensor imaging (DTI) could aid an early diagnosis, yet only few monocentric DTI studies in SCD have been conducted, reporting heterogeneous results. We investigated microstructural changes in SCD in a larger, multicentric cohort. 271 participants with SCD, mild cognitive impairment (MCI) or Alzheimer’s dementia (AD) and healthy controls (CON) were included, recruited prospectively at nine centers of the observational DELCODE study. DTI was acquired using identical protocols. Using voxel-based analyses, we investigated fractional anisotropy (FA), mean diffusivity (MD) and mode (MO) in the white matter (WM). Discrimination accuracy was determined by cross-validated elastic-net penalized regression. Center effects were explored using variance analyses. MO and FA were lower in SCD compared to CON in several anterior and posterior WM regions, including the anterior corona radiata, superior and inferior longitudinal fasciculus, cingulum and splenium of the corpus callosum (p
Databáze: OpenAIRE
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