Pharmacokinetics of ampicillin-sulbactam in healthy elderly and young volunteers
| Autor: | Meryl H. Mendelson, Burt R. Meyers, Shalom Z. Hirschman, S Walsh, Patricia Wilkinson, C Bournazos |
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| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.medical_specialty Urinary system Ampicillin/sulbactam Urine Gastroenterology Pharmacokinetics Internal medicine Ampicillin medicine polycyclic compounds Humans Pharmacology (medical) Volunteer Chromatography High Pressure Liquid Aged Pharmacology Aged 80 and over business.industry Half-life Sulbactam biochemical phenomena metabolism and nutrition Middle Aged Infectious Diseases Therapeutic Equivalency Anesthesia Drug Therapy Combination business medicine.drug Research Article Half-Life |
| Popis: | The pharmacokinetics of ampicillin-sulbactam in elderly subjects (65 to 85 years; group 3, n = 8), compared with those in middle-aged (41 to 64 years; group 2, n = 8) and younger (20 to 40 years; group 1, n = 8) subjects, were investigated. A single 2-g dose of ampicillin combined with 1 g of sulbactam in 60 ml of intravenous solution was administered to each subject over a 30-min period. Blood and urine samples were taken at baseline and serially over an 8.5-h period following the infusion. Ampicillin and sulbactam concentrations were assayed by high-performance liquid chromatography on a reversed-phase C-8 column. The mean levels in serum of both ampicillin and sulbactam were significantly higher for samples from group 3: for ampicillin from 1 through 8.5 h, and for sulbactam for the same time interval except at 5.5 h (P less than or equal to 0.05). The mean urinary excretion of both ampicillin and sulbactam was lowest, and urinary concentrations were highest in group 3. The areas under the serum drug concentration-time curve, the half-lives, and the maximum concentrations in serum were greatest, while the total clearance was lowest, for group 3 for both ampicillin and sulbactam. These results are consistent with a prolongation of antimicrobial activity of ampicillin-sulbactam in the elderly compared with that in younger subjects. |
| Databáze: | OpenAIRE |
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