Flavin dependent monooxygenases
| Autor: | Mieke M.E. Huijbers, Willem J. H. van Berkel, Adrie H. Westphal, S. Montersino, Dirk Tischler |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular Protein Conformation Stereochemistry Biophysics Biochemie Flavin group p-hydroxyphenylacetate 3-hydroxylase Biochemistry Cofactor Mixed Function Oxygenases Oxidoreductase Flavins Flavin reductase Animals Humans Systems and Synthetic Biology flavoprotein tryptophan 2-monooxygenase Molecular Biology VLAG chemistry.chemical_classification l-phenylalanine oxidase Systeem en Synthetische Biologie biology para-hydroxybenzoate hydroxylase Chemistry Monooxygenase sphingobium-xenophagum bayram Enzyme biology.protein l-lactate monooxygenase Light emission NAD+ kinase rh site-directed mutagenesis Oxidoreductases baeyer-villiger monooxygenases |
| Zdroj: | Archives of Biochemistry and Biophysics, 544, 2-17 Archives of Biochemistry and Biophysics 544 (2014) |
| ISSN: | 0003-9861 |
| Popis: | Flavin-dependent monooxygenases catalyze a wide variety of chemo-, regio- and enantioselective oxygenation reactions. As such, they are involved in key biological processes ranging from catabolism, detoxification and biosynthesis, to light emission and axon guidance. Based on fold and function, flavin-dependent monooxygenases can be distributed into eight groups. Groups A and B comprise enzymes that rely on NAD(P)H as external electron donor. Groups C–F are two-protein systems, composed of a monooxygenase and a flavin reductase. Groups G and H comprise internal monooxygenases that reduce the flavin cofactor through substrate oxidation. Recently, many new flavin-dependent monooxygenases have been discovered. In addition to posing basic enzymological questions, these proteins attract attention of pharmaceutical and fine-chemical industries, given their importance as regio- and enantioselective biocatalysts. In this review we present an update of the classification of flavin-dependent monooxygenases and summarize the latest advances in our understanding of their catalytic and structural properties. |
| Databáze: | OpenAIRE |
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