| Autor: |
Mrunal Sakharkar, Esper G. Kallas, Gorka Lasso, Lidiane Menezes Souza Raphael, Alexandra Tse, Kartik Chandran, Anna Z. Wec, Laura M. Walker, Nuria Pedreño-Lopez, Simone Sidoli, Zachary A. Bornholdt, Carolina Argondizo Correia, Yan Sun, Nathália Dias Furtado, Vivian Iida Avelino-Silva, Stephanie Stransky, Crystal L. Moyer, Myrna C. Bonaldo, Denise Haslwanter, David I. Watkins |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Cell Host Microbe |
| ISSN: |
1934-6069 |
| Popis: |
SummaryThe resurgence of yellow fever in South America has prompted mitigation through vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a virulent African isolate, and their capacity to induce neutralizing antibodies against the vaccine strain is widely used as a surrogate for protection. However, the sensitivity of genetically distinct South American strains to vaccine-induced antibodies is unknown. Here, we show that antiviral potency of the polyclonal antibody response in both U.S. and Brazilian vaccinees is attenuated against an emergent Brazilian strain. This reduction was attributable to genetic changes at two sites in the central domain II of the glycoprotein E, including the acquisition of an N–linked glycosylation site, which are unique to and shared among most South American YFV strains. Our findings call for a reevaluation of current approaches to YFV immunological surveillance in South America and suggest approaches for designing updated vaccines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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