Long-Term (≥25 Years) Kidney Allograft Survivors: Retrospective Analysis at a Single Center
| Autor: | Nikolaos Antoniadis, T. Deligiannidis, A. Tranta, G. Miserlis, A. Papagiannis, K. Karakasi, V. Papanikolaou, Georgios Katsanos, A. Zolota, A. Fouza, Ioannis Fouzas, C. Nikolaidou, N. Salveridis, C. Papadimitriou, F. Solonaki |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-sectional study Urology Renal function Kaplan-Meier Estimate Single Center Diabetes mellitus medicine Humans Survivors Survival analysis Aged Retrospective Studies Transplantation Kidney business.industry Graft Survival Retrospective cohort study Middle Aged medicine.disease Allografts Kidney Transplantation Tissue Donors medicine.anatomical_structure Cross-Sectional Studies Surgery Female business |
| Zdroj: | Transplantation proceedings. 52(10) |
| ISSN: | 1873-2623 |
| Popis: | Despite great improvements in the short-term patient and kidney graft survival, the long-term morbidity and mortality in kidney transplant recipients still remains a significant problem. The aim of the study was to evaluate the impact of both donor and transplant recipient factors, as well as renal function indices on the very long-term (25 years) kidney allograft survival.Retrospective analysis was performed on the data of 41 kidney transplant recipients (KTR), group A: follow-up = 25 years, 20 KTR, 10 male, mean age (mean [M] ± standard deviation [SD]): 34.6 ± 12.6 years, 14 living donors (LD), 6 cadaveric donors (CD); group B: follow-up25 years, 21 KTR, 16 male, mean age (M ± SD): 30.86 ± 12.37 years, 14 LD, 7 CD). Kidney graft origin, post-kidney transplantation diabetes mellitus, HLA compatibility, delayed graft function, and acute rejection episodes were also analyzed retrospectively. Statistical analysis with Mann-Whitney test and Kaplan-Meier survival analysis was performed (SPSS 20.0 for Windows).The mean age of CDs was lower than that of LDs: CD mean age (M ± SD): 23.84 ± 16.26 years vs LD mean age: 52.75 ± 12.42 years (P .001). Cadaveric kidney graft was associated with better renal allograft function 10, 15, and 25 years post kidney transplant. None of the other factors analyzed reached statistical significance between the 2 groups.The age of the donor and the kidney graft origin are important co-factors of the very long-term kidney allograft survival. |
| Databáze: | OpenAIRE |
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