| Popis: |
This study screened flavonoids and phenolic acids, antioxidant and cytotoxic effects of Mespilus germanica leaf and fruit samples. The RP-HPLC-DAD analysis allowed the identification of hesperidin, epicatechin, epigallocatechin, benzoic, p-hydroxybenzoic, vanillic, protocatechuic, syringic, caffeic, ferulic, sinapic and p-coumaric acids in various extracts. Fruit BHPA, leaf BPBH2, and leaf free flavan-3-ol extracts exhibited the largest DPPH, OH and NO radicals scavenging activity, respectively. Furthermore, fruit BPBH1, leaf BPAH2 and leaf BPBH1 extracts showed the highest ferrous ion chelation, ferric ion reducing power and FRAP value, respectively. Moreover, leaf flavone extract showed remarkable cytotoxicity on the HepG2 cell line (IC50 = 36.49±1.12 μg/mL) as well as strong •OH scavenging and Fe2+ chelation activities; similarly, leaf BPAH1 extract demonstrated excellent cytotoxicity on HeLa cell line (IC50 = 36.24±1.89 μg/mL). This study suggests Turkish medlar as a natural source of phenolic compounds with potential application in food and pharmaceutical industries as anticancer/antioxidant agents. |
