Fecal Calprotectin in Self-Reported Milk Intolerance: Not Only Lactose Intolerance
| Autor: | Seidita, Aurelio, Mansueto, Pasquale, Giuliano, Alessandra, Chiavetta, Marta, Soresi, Maurizio, Carroccio, Antonio, Group, the Internal Medicine Study Group the Internal Medicine Study |
|---|---|
| Přispěvatelé: | Seidita, Aurelio, Mansueto, Pasquale, Giuliano, Alessandra, Chiavetta, Marta, Soresi, Maurizio, Carroccio, Antonio, The Internal Medicine Study Group, null |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
cow’s milk proteins allergy
lactose intolerance lactose hydrogen breath test Settore MED/09 - Medicina Interna Nutrition and Dietetics LHBT milk intolerance SRMI fecal calprotectin LHBT SRMI cow’s milk proteins allergy fecal calprotectin lactose hydrogen breath test lactose intolerance milk intolerance Food Science |
| Zdroj: | Nutrients Volume 15 Issue 4 Pages: 1048 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu15041048 |
| Popis: | The hypothesis is that inflammatory/allergic conditions should be considered in self-reported milk intolerance (SRMI) patients who test negative and/or are asymptomatic at Lactose Hydrogen Breath Test (LHBT). We analyzed fecal calprotectin (FCP) values in SRMI patients to investigate the frequency of a “positive” intestinal inflammation marker and its correlation with lactose tolerance/intolerance. Data from 329 SRMI patients were retrospectively analyzed; according to the positive/negative results (maldigester/digester) and the presence/absence of symptoms reported during LHBT (intolerant/tolerant), patients were divided into: ‘lactose tolerants’ (n. 104), ‘maldigesters/intolerants’ (n. 187), ‘digesters/intolerants’ (n. 38). FCP values were analyzed in all three subgroups. A percentage of SRMI patients complained of constipation (>15%), extraintestinal symptoms (>30% including anemia), multiple food hypersensitivity (7.6%) and had intraepithelial lymphocytic infiltration at duodenal biopsy (>50%). Over 50.0% showed FCP values above the normal limit. Lactose tolerants and maldigesters/intolerants had higher positivity frequencies (p < 0.0001, for both) and absolute values (p = 0.04, for maldigesters/intolerants) of FCP compared to digesters/intolerants. FCP was not useful to differentiate tolerant from intolerant subjects (AUC 0.58). Our data suggest the existence of an allergic/inflammatory pathogenetic mechanism in a subset of SRMI subjects. FCP results are in keeping with this hypothesis, even if they cannot differentiate lactose tolerant from intolerant patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|