Klotho protein in neurodegenerative disorders
| Autor: | Monika Adamczyk-Sowa, Wojciech Bartman, Magdalena Torbus-Paluszczak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neurology Dermatology Review Article urologic and male genital diseases Neuroprotection Multiple sclerosis 03 medical and health sciences 0302 clinical medicine medicine Gene silencing Animals Humans Remyelination Klotho Klotho Proteins Glucuronidase business.industry Neurodegenerative Diseases General Medicine medicine.disease female genital diseases and pregnancy complications Klotho protein Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Cancer research Neurodegenerative disorders Choroid plexus Neurology (clinical) business 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Neurological Sciences |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | The Klotho protein is a recently discovered protein and its overexpression is associated with life extension. Klotho deficiency or silencing of the Klotho gene in mice leads to an accelerated aging and short life, whereas overexpression of Klotho in mice extends lifespan. Klotho participates in many metabolic pathways and is highly expressed in the kidneys, the choroid plexus and neurons. It plays a key role in the calcium-phosphate metabolism, remyelination, and cognitive processes. The present paper is a short review of the literature on the role of Klotho in neurodegenerative disorders, with special attention paid to multiple sclerosis. The neuroprotective function of Klotho is also reported. It is also important to consider potential clinical applications of Klotho that might be useful in the treatment of many diseases. |
| Databáze: | OpenAIRE |
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