CCR4-dependent regulatory T cell function in inflammatory bowel disease
Autor: | Shannon K. Bromley, Atul K. Bhan, Terry K. Means, Andrew D. Luster, Fumitaka Hayashi, Krister J. Jones, Qian Yuan |
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Jazyk: | angličtina |
Rok vydání: | 2007 |
Předmět: |
Adoptive cell transfer
Receptors CCR4 Regulatory T cell Immunology chemical and pharmacologic phenomena Inflammatory bowel disease T-Lymphocytes Regulatory TCIRG1 03 medical and health sciences Interleukin 21 Mice 0302 clinical medicine Immune system Immunology and Allergy Medicine Cytotoxic T cell Animals IL-2 receptor 030304 developmental biology Mice Knockout 0303 health sciences business.industry Brief Definitive Report hemic and immune systems medicine.disease Inflammatory Bowel Diseases Adoptive Transfer 3. Good health Mice Inbred C57BL medicine.anatomical_structure Brief Definitive Reports Lymph Nodes business 030215 immunology |
Zdroj: | The Journal of Experimental Medicine |
ISSN: | 1540-9538 0022-1007 |
Popis: | Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the intestine. CD4+ T lymphocytes play an important role in both initiating and regulating intestinal inflammatory immune responses. CD4+CD25+CD45RBlow regulatory T (T reg) cells are capable of preventing the development of colitis in a mouse model of IBD. The precise mechanism of T reg cell–mediated prevention of colitis in this model is unclear, and the role of chemokine receptors in the trafficking and function of T reg cells in this model has not been determined. We examined the role of the chemokine receptor CCR4 in in vivo trafficking and suppressive function of T reg cells in a mouse adoptive transfer model of IBD. CCR4-deficient T reg cells failed to accumulate in the mesenteric lymph nodes (MLNs) at early time points (2–5 d) after adoptive transfer, resulting in a failure to suppress the generation of pathogenic T cells and the development of colitis. Moreover, although CCR4-deficent T cells had equivalent in vitro suppressive activity and accumulated in MLNs at later time points (42–56 d), they were unable to suppress colitis. Our study demonstrates that CCR4 plays an important role in T reg cell trafficking in LNs and that this is critical for T reg cell suppressive function in vivo. |
Databáze: | OpenAIRE |
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