Apoe genotypes and brain imaging classes in normal cognition, mild cognitive impairment, and alzheimer’s disease: A longitudinal study
| Autor: | Rosolino Camarda, Carmela Pipia, Gianluca Sottile, Giovanna Cilluffo, Cecilia Camarda, Paola Torelli |
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| Přispěvatelé: | Camarda C., Torelli P., Pipia C., Sottile G., Cilluffo G., Camarda R. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Genotype Apolipoprotein E4 Neuroimaging Neuropsychological Tests APOE genotypes Brain imaging classes Caudate atrophy Global cerebral atrophy Lacunes White matter hyperintensities Aged Aged 80 and over Alzheimer Disease Apolipoprotein E4 Apolipoproteins E Brain Case-Control Studies Cognitive Dysfunction Disease Progression Female Genotype Humans Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged Neuroimaging Neuropsychological Tests Risk Factors brain imaging classes Apolipoproteins E Atrophy Alzheimer Disease Risk Factors Internal medicine Global brain atrophy medicine Humans Dementia Cognitive Dysfunction Longitudinal Studies caudate atrophy Aged global cerebral atrophy Aged 80 and over APOE genotypes business.industry Neuropsychology Brain Middle Aged white matter hyperintensities medicine.disease Magnetic Resonance Imaging Hyperintensity Neurology Case-Control Studies Disease Progression Cardiology Female Neurology (clinical) Alzheimer's disease business |
| Zdroj: | Current Alzheimer research (2020). doi:10.2174/1567205017666201109093314 info:cnr-pdr/source/autori:Cecilia Camarda; Paola Torelli ;Carmela Pipia ;Gianluca Sottile ; Giovanna Cilluffo ;Rosolino Camarda/titolo:APOE Genotypes and Brain Imaging Classes in Normal Cognition, Mild Cognitive Impairment, and Alzheimer's Disease: a Longitudinal Study/doi:10.2174%2F1567205017666201109093314/rivista:Current Alzheimer research (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| DOI: | 10.2174/1567205017666201109093314 |
| Popis: | Objective: To evaluate in 419 stroke-free cognitively normal subjects (CN) aged 45-82 years covering during a long prospective study (11.54 ± 1.47 years) the preclinical to dementia spectrum: 1) the distribution of small vessel disease (V) and brain atrophy (A) aggregated as following: V−/A−, V−/A+, V+/A−, V+/A+; 2) the relationship of these imaging classes with individual apolipoprotein E (APOE) genotypes; 3) the risk of progression to Alzheimer Disease (AD) of the individual APOE genotypes. Methods: Participants underwent one baseline (t0), and 4 clinical and neuropsychological assessments (t1,t2,t3, and t4). Brain MRI was performed in all subjects at t0, t2, t3 and t4.. White matter hyperintensities were assessed through two visual rating scales. Lacunes were also rated. Subcortical and global brain atrophy were determined through the bicaudate ratio and the lateral ventricle to brain ratio, respectively. APOE genotypes were determined at t0 in all subjects. Cox proportional hazard model was used to evaluate the risk of progression to AD. Results: The imaging class of mixed type was very common in AD, and in non amnestic mild cognitive impaired APOE ε4 non carriers. In these subjects, frontal and parieto-occipital regions were most affected by small vessel disease. Conclusion: Our findings suggest that the APOE ε3 allele is probably linked to the brain vascular pathology. |
| Databáze: | OpenAIRE |
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