Incidence and Outcomes of COVID-19 in Kidney and Liver Transplant Recipients With HIV: Report From the National HOPE in Action Consortium

Autor: Allan B. Massie, Aaron A.R. Tobian, Marcus R. Pereira, William A. Werbel, Nahel Elias, Meenakshi Rana, Megan Morsheimer, Jennifer D. Motter, Diane Brown, Dorry L. Segev, Sander Florman, Valentina Stosor, Brandy Haydel, Brian J. Boyarsky, Jacqueline Garonzik-Wang, Sapna A. Mehta, Catherine B. Small, Mark A. Robien, Jonah Odim, Christine M. Durand
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Transplantation
ISSN: 0041-1337
DOI: 10.1097/tp.0000000000003527
Popis: BACKGROUND: Transplant recipients with HIV may have worse outcomes with coronavirus disease 2019 (COVID-19) due to impaired T-cell function coupled with immunosuppressive drugs. Alternatively, immunosuppression might reduce inflammatory complications and/or antiretrovirals could be protective. METHODS: Prospective reporting of all cases of SARS-CoV-2 infection was required within the HOPE in Action Multicenter Consortium, a cohort of kidney and liver transplant recipients with HIV who have received organs from donors with and without HIV at 32 transplant centers in the United States. RESULTS: Between March 20, 2020 and September 25, 2020, there were 11 COVID-19 cases among 291 kidney and liver recipients with HIV (4%). In those with COVID-19, median age was 59 y, 10 were male, 8 were kidney recipients, and 5 had donors with HIV. A higher proportion of recipients with COVID-19 compared with the overall HOPE in the Action cohort were Hispanic (55% versus 12%) and received transplants in New York City (73% versus 34%, P < 0.05). Most (10/11, 91%) were hospitalized. High-level oxygen support was required in 7 and intensive care in 5; 1 participant opted for palliative care instead of transfer to the intensive care unit. HIV RNA was undetectable in all. Median absolute lymphocyte count was 0.3 × 103 cells/µL. Median CD4 pre-COVID-19 was 298 cells/µL, declining to
Databáze: OpenAIRE