Metastatic choriocarcinoma successfully treated with paclitaxel and carboplatin after interstitial lung disease induced by EMA-CO
| Autor: | Kenichi Tanaka, Yoichi Aoki, Nobumichi Nishikawa, Tomokazu Yokoo, Mina Suzuki, Chiaki Banzai, Masayuki Sekine, Takayuki Amikura |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Lung Neoplasms Paclitaxel medicine.medical_treatment Gastroenterology Carboplatin Gestational choriocarcinoma chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Choriocarcinoma Cyclophosphamide Etoposide Chemotherapy medicine.diagnostic_test business.industry Liver Neoplasms Interstitial lung disease Obstetrics and Gynecology Combination chemotherapy medicine.disease Chemotherapy regimen Regimen Methotrexate Bronchoalveolar lavage chemistry Vincristine Uterine Neoplasms Dactinomycin Female Lung Diseases Interstitial business |
| Zdroj: | Gynecologic Oncology. 102:573-575 |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/j.ygyno.2006.02.031 |
| Popis: | Well-established first-line chemotherapy (such as EMA-CO) is extraordinary active for gestational choriocarcinoma. However, it causes very serious situation once drug-induced acute interstitial lung disease occurs during the treatment.A 31-year-old Japanese woman with metastatic choriocarcinoma was treated with EMA-CO as an initial chemotherapy regimen for seven cycles. Her beta-hCG dropped from 13,087 ng/ml to 2.2 ng/ml. At 11 days after 7th cycle of EMA-CO treatment, however, she developed respiratory failure, and was diagnosed as having EMA-CO-induced interstitial lung disease with bilateral ground-glass opacity on CT scan, and the examination of the bronchoalveolar lavage fluid. After high-dose steroid therapy, symptoms and ground-glass opacity on CT scan were remarkably improved. She then commenced a regimen of carboplatin (AUC 5) and paclitaxel (180 mg/m2). After completing 8 cycles, her beta-hCG dropped to0.2 ng/ml. Three additional cycles were administered and the patient remained clinically free of disease, with normal beta-hCG levels for 11 months.Paclitaxel and carboplatin combination is active and appears to be a viable alternative to EMA-CO combination chemotherapy in metastatic choriocarcinoma even after EMA-CO-induced interstitial lung disease. |
| Databáze: | OpenAIRE |
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