Mining genomes to illuminate the specialized chemistry of life
| Autor: | Bradley S. Moore, Tristan de Rond, Marnix H. Medema |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Integrative omics
Bioinformatics Plant Biology Computational biology Biology Genome Article Organic molecules 03 medical and health sciences 0302 clinical medicine Drug Discovery Bioinformatica Genetics Life Science Animals Humans Molecular Biology Genetics (clinical) 030304 developmental biology 0303 health sciences Biological Products Bacteria Extramural Human Genome Fungi Computational Biology Genomics Plants Genomic information Genome mining Generic health relevance Biochemistry and Cell Biology 030217 neurology & neurosurgery Biotechnology Developmental Biology |
| Zdroj: | Nature Reviews Genetics, 22(9), 553-571 Nat Rev Genet Nature reviews. Genetics, vol 22, iss 9 Nature Reviews Genetics 22 (2021) 9 |
| ISSN: | 1471-0056 |
| Popis: | All organisms produce specialized organic molecules, ranging from small volatile chemicals to large gene-encoded peptides, that have evolved to provide them with diverse cellular and ecological functions. As natural products, they are broadly applied in medicine, agriculture and nutrition. The rapid accumulation of genomic information has revealed that the metabolic capacity of virtually all organisms is vastly underappreciated. Pioneered mainly inbacteria and fungi, genome mining technologies are accelerating metabolite discovery. Recent efforts are now being expanded to all life forms, including protists, plants and animals, and new integrative omics technologies are enabling the increasingly effective mining of this molecular diversity. |
| Databáze: | OpenAIRE |
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