The switch of DNA states filtering the extrinsic noise in the system of frequency modulation
| Autor: | Bo-Ren Chen, Che-Chi Shu, Shih-Chiang Lo, Ching-Chu Hsieh, Chao-Xuan You, Cheng-En Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Distribution (number theory)
Transcription Genetic Operon Science Noise (electronics) Article Gene regulatory networks chemistry.chemical_compound Stochastic simulation Escherichia coli Upstream (networking) Computer Simulation Physics Multidisciplinary Escherichia coli Proteins DNA Gene Expression Regulation Bacterial chemistry Medicine Node (circuits) Biological system Frequency modulation Transcription Transcription Factors |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
| ISSN: | 2045-2322 |
| Popis: | There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits inspired by the fim operon in Escherichia coli, we found that cells exchanged the distribution of the upstream transcription factor (TF) for the transitional frequency of DNA. Then cells do an inverse transform, which exchanges the transitional frequency of DNA for the distribution of downstream products. Due to this special feature, DNA in the system of frequency modulation is able to reset the noise. By probability generating function, we know the ranges of parameter values that grant such an interesting phenomenon. |
| Databáze: | OpenAIRE |
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