Spectrum of bone marrow morphologic findings in hepatitis C patients with and without prior liver transplantation
| Autor: | J. M. Boone, Wei Cui |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Cirrhosis Myeloid Pancytopenia medicine.medical_treatment Clinical Biochemistry Liver transplantation 03 medical and health sciences 0302 clinical medicine Bone Marrow hemic and lymphatic diseases Neoplasms medicine Humans Retrospective Studies Cytopenia medicine.diagnostic_test business.industry Biochemistry (medical) Complete blood count Bone Marrow Examination Hematology General Medicine Hepatitis C Plasma cell neoplasm medicine.disease Liver Transplantation medicine.anatomical_structure 030211 gastroenterology & hepatology business 030215 immunology |
| Zdroj: | International journal of laboratory hematology. 38(6) |
| ISSN: | 1751-553X |
| Popis: | SummaryIntroduction Cytopenia is a common hematologic finding in patients with HCV infection. Only a few studies have addressed bone marrow (BM) morphologic findings in these patients. No systemic study has been performed in these patients with liver transplantation (LT). Methods We retrospectively examined BMs in 49 hepatitis C patients with and without prior LT (n = 19 and n = 30). Results Among the patients with an available complete blood count (n = 46), the majority of them presented with cytopenia involving one or multiple cell lineages including unicytopenia (13%, n = 6), bicytopenia (31%, n = 14), and pancytopenia (43%, n = 20). Examination of the BM revealed a wide spectrum of morphologic findings ranging from benign reactive processes to overt malignant processes which included myeloid, lymphoid, and plasma cell neoplasms. The severity of cytopenia was not correlated with cirrhosis or antiviral therapy. However, the severity of cytopenia was partly correlated with splenomegaly or LT (P < 0.05). Conclusions Cytopenia is a common finding in hepatitis C patients. Hypersplenism or LT has an adverse impact on some blood cell counts. Lastly, hepatitis C patients present with a wide spectrum of BM findings including malignant neoplasms, which indicates a diagnostic value of BM examination in these patients. |
| Databáze: | OpenAIRE |
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