Threatening drug‐drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID‐19)
| Autor: | Beatrice Borchi, Marilù Bartiromo, Gianmarco Lugli, Roberta Cutruzzulà, Aida Larti, Silvia Bresci, Calogero Cirami, Augusto Vaglio, Alfredo Bagalà, Annalisa Cavallo, Brunilda Xhaferi, Alessandro Bartoloni, Annarita Botta, Marta Tilli |
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| Rok vydání: | 2020 |
| Předmět: |
Graft Rejection
Interleukin-1beta Leber Congenital Amaurosis Common Cold 030230 surgery Severity of Illness Index Lopinavir Organ transplantation Deprescriptions 0302 clinical medicine drug‐drug interaction Drug Interactions Enzyme Inhibitors Fatigue Kidney transplantation Darunavir education.field_of_study Cobicistat Kidney Diseases Cystic Interleukin-10 Drug Combinations C-Reactive Protein Infectious Diseases Pharmaceutical Preparations Female 030211 gastroenterology & hepatology Coronavirus Infections Immunosuppressive Agents Hydroxychloroquine medicine.drug kidney transplant Adult medicine.medical_specialty Short Communication Pneumonia Viral Population Antiviral Agents Methylprednisolone Tacrolimus Betacoronavirus Immunocompromised Host 03 medical and health sciences Optic Atrophies Hereditary COVID‐19 Internal medicine medicine Humans education Glucocorticoids Pandemics Transplantation Ritonavir Interleukin-6 SARS-CoV-2 business.industry Interleukin-8 COVID-19 Pneumonia medicine.disease Kidney Transplantation Transplant Recipients Ciliopathies COVID-19 Drug Treatment Cough Cytochrome P-450 CYP3A Inhibitors Kidney Failure Chronic business |
| Zdroj: | Transplant Infectious Disease |
| ISSN: | 1399-3062 1398-2273 |
| DOI: | 10.1111/tid.13286 |
| Popis: | During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long‐term immunosuppressive therapy. For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. We present the case of a 36‐year‐old kidney transplanted woman affected by Senior‐Loken syndrome diagnosed with COVID‐19 pneumonia after a contact with her positive mother. Initial symptoms were fatigue, dry cough and coryza; she never had fever nor oxygen supplementation. Hydroxychloroquine and lopinavir/ritonavir were started, and the antiviral drug was replaced with darunavir/cobicistat after two days for diarrhea. Immunosuppressant levels were closely monitored, and we observed very high tacrolimus trough levels despite initial dose reduction. The patient was left with steroid therapy alone. The peculiarity of clinical presentation and the management difficulties represent the flagship of our case‐report. We stress the need for guidelines in transplant recipients with COVID‐19 infection with particular regard to the management of therapy. |
| Databáze: | OpenAIRE |
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