Evaluation of Antimicrobial Susceptibility Profile in Salmonella Typhi and Salmonella Paratyphi A: Presenting the Current Scenario in India and Strategy for Future Management
| Autor: | Arti Kapil, Temsunaro Rongsen-Chandola, Dasaratha Ramaiah Jinka, Pallab Ray, Jobin John Jacob, Ashita Singh, Madhu Gupta, Raghuprakash Reddy Nayakanti, Jayanthi Shastri, Anuradha De, Agila Kumari Pragasam, Roshine Mary Koshy, Sonali Sanghavi, Shanta Dutta, Anushree Amladi, Anna P Alexander, Deepak More, Maria Thomas, Dhiviya Prabaa Muthuirulandi Sethuvel, Ashish Bavdekar, Baby S Abirami, Yamuna Devi Bakthavatchalam, Sulochana Putli Bai Perumal, Karnika Saigal, Jacob John, Balaji Veeraraghavan, Shalini Anandan, Savitha Nagaraj, Gagandeep Kang, Sheena Evelyn Ebenezer |
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| Rok vydání: | 2022 |
| Předmět: |
Salmonella
Antimicrobial susceptibility India Microbial Sensitivity Tests Biology Azithromycin Salmonella typhi medicine.disease_cause Microbiology Ciprofloxacin Drug Resistance Bacterial medicine Immunology and Allergy Humans Typhoid Fever Ceftriaxone Salmonella paratyphi A Salmonella Paratyphi Anti-Bacterial Agents Infectious Diseases medicine.drug |
| Zdroj: | The Journal of infectious diseases. 224(Supple 5) |
| ISSN: | 1537-6613 |
| Popis: | BackgroundSystematic studies to estimate the disease burden of typhoid and paratyphoid in India are limited. Therefore, a multicenter study on the Surveillance of Enteric Fever in India was carried out to estimate the incidence, clinical presentation, and antimicrobial resistance (AMR) trend. The data presented here represent the national burden of AMR in Salmonella Typhi and Salmonella Paratyphi A.MethodsAntimicrobial susceptibility testing was performed for S. Typhi and S. Paratyphi A (n = 2373) isolates collected prospectively during a 2-year period from November 2017 to January 2020.ResultsOf 2373 Salmonella isolates, 2032 (85.6%) were identified as S. Typhi and 341 (14.4%) were S. Paratyphi A. Approximately 2% of S. Typhi were multidrug-resistant (MDR), whereas all 341 (100%) of S. Paratyphi A isolates were sensitive to the first-line antimicrobials. Among 98% of ciprofloxacin nonsusceptible isolates, resistance (minimum inhibitory concentration [MIC] >0.5 µg/mL) was higher in S. Typhi (37%) compared with S. Paratyphi A (20%). Azithromycin susceptibility was 99.9% and 100% with a mean MIC of 4.98 μg/mL for S. Typhi and 7.39 μg/mL for S. Paratyphi A respectively. Ceftriaxone was the only agent that retained 100% susceptibility. Moreover, beta-lactam/beta-lactamase inhibitors showed potent in vitro activity against the study isolates.ConclusionsData obtained from this systematic surveillance study confirms the declining trend of MDR Salmonella isolates from India. The higher prevalence of ciprofloxacin nonsusceptibility enforces to limit its use and adhere to the judicious usage of azithromycin and ceftriaxone for enteric fever management. |
| Databáze: | OpenAIRE |
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