Glyceryl Monostearate: Probing the Self Assembly of a Lipid Amenable To Surface Modification for Hepatic Targeting
| Autor: | Alex Bunker, Debes Ray, Mangal S. Nagarsenker, Vinod K. Aswal, Megha Marwah, Aniket Magarkar |
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| Přispěvatelé: | Faculty of Pharmacy, Drug Research Program, Division of Pharmaceutical Biosciences, Pharmaceutical biophysics group |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
food.ingredient 116 Chemical sciences LIPOSOMES 02 engineering and technology ANGLE NEUTRON-SCATTERING Glyceryl monostearate 03 medical and health sciences chemistry.chemical_compound food NANOPARTICLES Physical and Theoretical Chemistry AMPHIPHILES Chromatography Food additive Monoglyceride UNILAMELLAR VESICLES 021001 nanoscience & nanotechnology LIGHT-SCATTERING Surfaces Coatings and Films Electronic Optical and Magnetic Materials 030104 developmental biology General Energy chemistry MOLECULAR-DYNAMICS 317 Pharmacy 216 Materials engineering PHASE-TRANSITION FORCE-FIELD 5-FLUOROURACIL Surface modification lipids (amino acids peptides and proteins) 221 Nano-technology 0210 nano-technology |
| Zdroj: | The Journal of Physical Chemistry C. 122:22160-22169 |
| ISSN: | 1932-7455 1932-7447 |
| Popis: | Glyceryl monostearate (GMS) is a single-tailed lipidic monoglyceride commonly used as a nontoxic food additive. In this study, we have investigated GMS, specifically its self-assembling properties and subsequent application in drug delivery. Results from in silico modeling, corroborated by complementary small-angle neutron scattering, demonstrated vesicle formation; associated phase transitions were analyzed using differential scanning calorimetry; dynamic light scattering revealed particle size alterations that occurred in the transition region. Spherical morphology of unilamellar vesicles was visualized using transmission electron microscopy imaging. Further, hydrophilic and hydrophobic drug loading in GMS vesicles and their amenability to surface modification for hepatic targeting have, in this study, been both predicted through molecular simulation study and demonstrated experimentally. The influence of hepatotropic ligands on the stability of drug-loaded GMS vesicles vis-a-vis cholesterol has also been investigated; the resulting GMS-based drug delivery vehicle, its properties enhanced through surface decoration, is envisaged to achieve targeted delivery of its payload to hepatocytes. |
| Databáze: | OpenAIRE |
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