Subclinical disease burden as assessed by whole-body MRI in subjects with prediabetes, subjects with diabetes, and normal control subjects from the general population: the KORA-MRI Study
| Autor: | Katharina Müller-Peltzer, Christa Meisinger, Michael Ingrisch, Margit Heier, Susanne Rospleszcz, Birgit Linkohr, Tanja Zitzelsberger, Christian Weber, Tobias Saam, Andreas Schindler, Christopher L. Schlett, Christian Bayerl, Wieland H. Sommer, Maximilian F. Reiser, Birgit Ertl-Wagner, Sigrid Auweter, Wolfgang Rathmann, Roberto Lorbeer, Anina Schafnitzel, Sonja Selder, Steffen Massberg, Jürgen Machann, Holger Hetterich, Annette Peters, Fabian Bamberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Population 030204 cardiovascular system & hematology Intra-Abdominal Fat 030218 nuclear medicine & medical imaging Coronary artery disease Prediabetic State 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Diabetes Mellitus Humans Prediabetes education Stroke Aged education.field_of_study business.industry Myocardium Case-control study Glucose Tolerance Test Middle Aged medicine.disease Magnetic Resonance Imaging Hyperintensity Endocrinology Adipose Tissue Liver Case-Control Studies Cohort Cardiology business |
| Zdroj: | Diabetes 66, 158-169 (2017) |
| Popis: | Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, coronary artery disease, or peripheral artery disease were enrolled in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and underwent comprehensive MRI assessment to characterize cerebral parameters (white matter lesions, microbleeds), cardiovascular parameters (carotid plaque, left ventricular function, and myocardial late gadolinium enhancement [LGE]), and metabolic parameters (hepatic proton-density fat fraction [PDFF] and subcutaneous and visceral abdominal fat). Among 400 subjects who underwent MRI, 103 subjects had prediabetes and 54 had established diabetes. Subjects with prediabetes had an increased risk for carotid plaque and adverse functional cardiac parameters, including reduced early diastolic filling rates as well as a higher prevalence of LGE compared with healthy control subjects. In addition, people with prediabetes had significantly elevated levels of PDFF and total and visceral fat. Thus, subjects with prediabetes show early signs of subclinical disease that include vascular, cardiac, and metabolic changes, as measured by whole-body MRI after adjusting for cardiometabolic risk factors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|