Infective Endocarditis Manifesting as Severe Elevation in Serum Aminotransferases in the Absence of Severe Tricuspid Regurgitation, Heart Failure, or Shock: A Diagnostic Challenge
| Autor: | Richard Snyder, Emily B Ernst, James Kamau, Mathai Chalunkal, Jason A Hoggard, Eluwana A Amaratunga |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Antibiotics Cardiology Infectious Disease Signs and symptoms Regurgitation (circulation) blood cultures Internal medicine blood culture negative endocarditis Internal Medicine transaminitis medicine elevated liver associated enzymes duke criteria Liver injury infective endocarditis business.industry aminotransferases General Engineering medicine.disease Congestive hepatopathy Infective endocarditis Heart failure Shock (circulatory) medicine.symptom business liver injury |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.16044 |
| Popis: | Infective endocarditis (IE) is a challenging condition to diagnose, given its protean clinical signs and symptoms, Elevation in serum aminotransferases in IE is associated with valvular regurgitation, acute heart failure, or congestive hepatopathy. Studies show co-existing liver failure portends worsening outcomes in IE and poses a challenge for successful surgical management. Here we report a diagnostic challenge in a 35-year-old man with IE presenting predominantly with gastrointestinal symptoms and severe elevation in serum aminotransferase. The degree of aminotransferase elevation in our patient prompted consideration of alternative causes like acetaminophen toxicity. Severe elevation in aminotransferases as an initial presentation in the absence of significant valvular regurgitation, acute right heart failure, or shock is uncommon. A high degree of suspicion is required to diagnose IE when patients present with atypical signs and symptoms to avoid delay in initiation of antibiotics and improve overall morbidity and mortality. |
| Databáze: | OpenAIRE |
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