Survival differences in nasopharyngeal carcinoma among racial and ethnic minority groups in the United States: A retrospective cohort study
| Autor: | Jastin L. Antisdel, Sai D Challapalli, Nosayaba Osazuwa-Peters, Ronald J. Walker, Greg M. Ward, Matthew C. Simpson, Eric Adjei Boakye |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Population 03 medical and health sciences 0302 clinical medicine Survivorship curve Ethnicity Humans Medicine 030223 otorhinolaryngology education Survival rate Survival analysis Retrospective Studies education.field_of_study Nasopharyngeal Carcinoma business.industry Hazard ratio Retrospective cohort study Middle Aged Prognosis Survival Analysis United States Health equity Otorhinolaryngology 030220 oncology & carcinogenesis Pacific islanders Female business SEER Program Demography |
| Zdroj: | Clinical Otolaryngology. 44:14-20 |
| ISSN: | 1749-4478 |
| DOI: | 10.1111/coa.13225 |
| Popis: | OBJECTIVE The literature on nasopharyngeal carcinoma survival in the United States has focused mostly on Whites or Asians and not much is known about survivorship in other minority racial and ethnic groups. We aimed to determine the disease-specific survival rate and prognostic factors for nasopharyngeal carcinoma survival across the minority United States population. DESIGN A retrospective cohort study. SETTING The Surveillance, Epidemiology and End Results (SEER) 13 database from 1992 to 2014 was queried for adult cases of nasopharyngeal carcinoma (n = 2549). PARTICIPANTS Eligible cases were Blacks, Hispanics, Asians/Pacific Islanders, American Indians/Alaska Natives; White patients were excluded. MAIN OUTCOMES MEASURE A multivariable competing risk survival analysis yielded hazard ratios (HR) for competing mortality and was used to identify independent prognostic factors for survival. RESULTS Non-Hispanic American Indians/Alaska Natives consistently had the worst cause-specific survival of any group and that non-Hispanic Asians/Pacific Islanders consistently had the best survival (P < 0.001). Even after adjusting for other poor prognostic factors in the study, including older age, keratinising histology, and lack of radiation treatment, non-Hispanic American Indians/Alaska Natives had more than double hazards of death from nasopharyngeal cancer compared with non-Hispanic Asians/Pacific Islanders (aHR = 2.63, 95% CI 1.67, 4.13). CONCLUSIONS There are disparities in nasopharyngeal carcinoma survival among racial and ethnic minority groups in the United States, with American Indians/Alaskan Natives faring worst. It is critical that future research focuses on nasopharyngeal carcinoma among this population to improve survivorship and mitigate cancer-related health disparities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text